Elucidation of association between retinal ganglion cell death and extracellular matrix in various models of optic nerve degeneration
Elucidation of association between retinal ganglion cell death and extracellular matrix in various models of optic nerve degeneration
批准号:
19390444
负责人:
NEGI Akira
金额:
$7.57万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
There was a substantial difference in magnitude, spatial distribution, and time course of apoptotic death of retinal ganglion cells among three models of optic nerve degeneration induced by diabetes, optic nerve crush, and glaucoma. The changes in aquaporin expression in the retinal ganglion cells and glia in the retina and optic nerve were significantly different among these three models. Besides, the possibility was also demonstrated that the optic nerved degeneration in human glaucoma eyes reflects the scleral biomechanics.
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The Regional Relationship Between Retinal Nerve Fiber Layer Thickness and Corresponding Visual Field Sensitivity
视网膜神经纤维层厚度与相应视野敏感度的区域关系
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Akiyasu Kanamori, Maiko Naka, Miyuki Fujioka, Yasuko Tatsumi, Azusa Kusuhara-Nagai, Yuko Yamada, Makoto Nakamura, Akira Negi]
通讯作者:
Akira Negi
DOI:
10.1007/s00417-009-1122-6
发表时间:
2009-10-01
期刊:
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
影响因子:
2.7
作者:
[Kanamori, Akiyasu, Naka, Maiko, Negi, Akira]
通讯作者:
Negi, Akira
Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.
Toll 样受体 2 基因多态性与正常眼压性青光眼的关联。
DOI:
--
发表时间:
2009
期刊:
Mol Vis 15
影响因子:
--
作者:
[Nakamura J, Meguro A, Ota M, Nomura E, Nishide T, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, I]
通讯作者:
I
cAMP-responsive element binding protein mediates a cGMP/protein kinase G-dependent anti-apoptotic signal induced by nitric oxide in retinal neuro-glial progenitor cells.
cAMP 响应元件结合蛋白介导视网膜神经胶质祖细胞中一氧化氮诱导的 cGMP/蛋白激酶 G 依赖性抗凋亡信号。
DOI:
--
发表时间:
2007
期刊:
Exp Eye Res. 84
影响因子:
--
作者:
[Naga i-Kusuhara A, Nakamura M, Mukuno H, Kanamori A, Negi A, Seigel GM.]
通讯作者:
Seigel GM.
Association of retinal nerve fiber layer thickness measured by confocal scanning laser ophthalmoscopy and optical coherence tomography with disc size and axial length.
通过共焦扫描激光检眼镜和光学相干断层扫描测量的视网膜神经纤维层厚度与椎间盘大小和轴长的关系。
DOI:
--
发表时间:
2008
期刊:
British Journal of Ophthalmology 92・2
影响因子:
--
作者:
[Azusa, Nagai-Kusuhara, Nagai-Kusuhara Azusa]
通讯作者:
Nagai-Kusuhara Azusa
共 29 条
Elucidation ofpathogenesis and establishment of objective assessment for intraocular pressure-dependent optic nerve damage
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批准号:22390324
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.82万
-
财政年份:2010
-
负责人:NEGI Akira
-
依托单位:
Analysis of aberrant retinal neuro-glial relationship in glaucoma and diabetic retinopathy
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批准号:16390499
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.18万
-
财政年份:2004
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负责人:NEGI Akira
-
依托单位:
Analysis of intraretinal neuro-glial interaction in glaucoma
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批准号:14571672
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2002
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负责人:NEGI Akira
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依托单位:
Studies on the mechanisms of sensory retinal adhesion, its breakdown and reconstruction
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批准号:11671746
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.02万
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财政年份:1999
-
负责人:NEGI Akira
-
依托单位:
INVESTIGATION ABOUT THE MECHANISM OF RETINAL ADHESION AND ITS BREAKDOWN AND RECOVERY
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批准号:07457413
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.8万
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财政年份:1995
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负责人:NEGI Akira
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依托单位:
海外基金