Elucidation of association between retinal ganglion cell death and extracellular matrix in various models of optic nerve degeneration

阐明各种视神经变性模型中视网膜神经节细胞死亡与细胞外基质之间的关联

• 批准号: 19390444
• 负责人: NEGI Akira
• 金额: $ 7.57万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390444/
• 关键词: 緑内障; 糖尿病網膜症; 視神経変性; 細胞外基質特性; 網膜神経節細胞死; 水チャンネル; アクアポリン; 視神経; 網膜神経節細胞; グリア細胞; アポトーシス; 視神経挫滅; 慢性高眼圧; 糖尿病網膜証; 軸索輸送

There was a substantial difference in magnitude, spatial distribution, and time course of apoptotic death of retinal ganglion cells among three models of optic nerve degeneration induced by diabetes, optic nerve crush, and glaucoma. The changes in aquaporin expression in the retinal ganglion cells and glia in the retina and optic nerve were significantly different among these three models. Besides, the possibility was also demonstrated that the optic nerved degeneration in human glaucoma eyes reflects the scleral biomechanics.

糖尿病、视神经挤压和青光眼引起的视神经变性的三种模型中，视网膜神经节细胞凋亡的幅度、空间分布和时程存在实质性差异。视网膜神经节细胞、视网膜和视神经胶质细胞水通道蛋白表达的变化在三种模型中有显著性差异。此外，还证实了青光眼视神经变性反映巩膜生物力学的可能性。

项目成果

Tafluprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo

• DOI: 10.1007/s00417-009-1122-6
• 发表时间: 2009-10-01
• 期刊: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
• 影响因子: 2.7
• 作者: Kanamori, Akiyasu;Naka, Maiko;Negi, Akira
• 通讯作者: Negi, Akira

The Regional Relationship Between Retinal Nerve Fiber Layer Thickness and Corresponding Visual Field Sensitivity

视网膜神经纤维层厚度与相应视野敏感度的区域关系

• 发表时间: 2007
• 作者: Akiyasu Kanamori;Maiko Naka;Miyuki Fujioka;Yasuko Tatsumi;Azusa Kusuhara-Nagai;Yuko Yamada;Makoto Nakamura;Akira Negi
• 通讯作者: Akira Negi

Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.

Toll 样受体 2 基因多态性与正常眼压性青光眼的关联。

• 发表时间: 2009
• 期刊: Mol Vis 15
• 作者: Nakamura J;Meguro A;Ota M;Nomura E;Nishide T;Kashiwagi K;Mabuchi F;Iijima H;Kawase K;Yamamoto T;Nakamura M;Negi A;Sagara T;Nishida T;Inatani M;Tanihara H;Aihara M;Araie M;Fukuchi T;Abe H;Higashide T;Sugiyama K;Kanamoto T;Kiuchi Y;I
• 通讯作者: I

cAMP-responsive element binding protein mediates a cGMP/protein kinase G-dependent anti-apoptotic signal induced by nitric oxide in retinal neuro-glial progenitor cells.

cAMP 响应元件结合蛋白介导视网膜神经胶质祖细胞中一氧化氮诱导的 cGMP/蛋白激酶 G 依赖性抗凋亡信号。

• 发表时间: 2007
• 期刊: Exp Eye Res. 84
• 作者: Naga i-Kusuhara A;Nakamura M;Mukuno H;Kanamori A;Negi A;Seigel GM.
• 通讯作者: Seigel GM.

Association of retinal nerve fiber layer thickness measured by confocal scanning laser ophthalmoscopy and optical coherence tomography with disc size and axial length.

通过共焦扫描激光检眼镜和光学相干断层扫描测量的视网膜神经纤维层厚度与椎间盘大小和轴长的关系。

• 发表时间: 2008
• 期刊: British Journal of Ophthalmology 92・2
• 作者: Azusa;Nagai-Kusuhara;Nagai-Kusuhara Azusa
• 通讯作者: Nagai-Kusuhara Azusa