Elucidation of association between retinal ganglion cell death and extracellular matrix in various models of optic nerve degeneration

糖尿病、视神经压迫和青光眼三种视神经变性模型中，视网膜神经节细胞凋亡的大小、空间分布和时间过程均有显著差异。三种模型的视网膜神经节细胞及视网膜和视神经胶质细胞中水通道蛋白的表达变化均有显著差异。此外，也证明了视神经退行性变反映了人类青光眼巩膜生物力学的可能性。

There was a substantial difference in magnitude, spatial distribution, and time course of apoptotic death of retinal ganglion cells among three models of optic nerve degeneration induced by diabetes, optic nerve crush, and glaucoma. The changes in aquaporin expression in the retinal ganglion cells and glia in the retina and optic nerve were significantly different among these three models. Besides, the possibility was also demonstrated that the optic nerved degeneration in human glaucoma eyes reflects the scleral biomechanics.