权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Effect of Angiogenesis Inhibitors on Tongue Carcinoma Induced by 4-Nitroquinoline 1-Oxide (4NQO) on Rats

血管生成抑制剂对4-硝基喹啉1-氧化物(4NQO)诱导的大鼠舌癌的作用

基本信息

批准号：
11671882
负责人：
KATAKURA Akira
金额：
$ 1.66万
依托单位：
TOKYO DENTAL COLLEGE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

Ever since we established 4-nitroquinoline 1-oxide-induced rat tongue cancer models, we have been actively conducting research on vascularity. This time, we administered angiogenesis inhibitors (5-DFUR, actinon, and anti-integrin antibody) to compare their effects on the growth of two types of tongue cancer (Group A : outgrowing tumors having ring-shaped or reticulated vessels, and Group B : tumors that have branch-like vessels or destroy existing vessels). Every inhibitor suppressed the growth of Group A tumors more than that of Group B tumors. This tendency was markedly strong for outgrowing tumors with reticulated vessels. However, none of the tumors completely disappeared, and the maximum tumor diameter reduction was 70%. We examined changes in tumor vessels by scanning microscopy or vessel template analysis, and found that tumor vessels at the tip of tumor growth formed beads and were narrow. When these inhibitors were not administered, branches eventually formed from feeding vessels, but when these inhibitors were administered, the growth of branches was terminated (branches formed beads). These findings were mostly similar to the results of animal studies on various anticancer drugs, but these inhibitors suppressed tumor growth more than antimetabolic agents. In the future, it will be important to : enhance anticancer effects by coadministering anticancer agents and angiogenesis inhibitors ; and improve drug delivery to tumors in which existing blood vessels have been destroyed.

自从我们建立了4-硝基喹啉-1-氧化物诱导的大鼠舌癌模型以来，我们一直在积极地进行血管方面的研究。这一次，我们应用血管生成抑制剂(5-DFUR、放线菌素和抗整合素抗体)来比较它们对两种类型舌癌生长的影响(A组：长出的肿瘤有环状或网状血管，B组：有分支状血管或破坏现有血管的肿瘤)。各抑制物对A组肿瘤生长的抑制作用均强于B组。这一趋势在网状血管生长的肿瘤中表现得尤为明显。但无一例肿瘤完全消失，肿瘤最大缩径70%。我们通过扫描显微镜或血管模板分析检测肿瘤血管的变化，发现肿瘤生长尖端的肿瘤血管形成珠状且狭窄。当不给予这些抑制剂时，最终会从供血的血管中形成分支，但当给予这些抑制剂时，分支的生长就会终止(分支形成珠子)。这些发现与各种抗癌药物的动物研究结果基本相似，但这些抑制剂对肿瘤生长的抑制作用强于抗代谢药物。在未来，重要的是：通过联合应用抗癌药物和血管生成抑制剂来增强抗癌效果；并改善对现有血管被破坏的肿瘤的药物输送。