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The investigation of mechanisms between PDT and metastatic effect of oral cancer

The investigation of mechanisms between PDT and metastatic effect of oral cancer
PDT与口腔癌转移作用的机制研究
批准号：
11672026
负责人：
YOSHIDA Kenji
金额：
$1.54万
依托单位：
Aichi-Gakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
项目状态：
已结题
起止时间：
1999 至 2001
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11672026/
关键词：
photodynamic therapyPDTmetastasis転移培養癌細胞悪性腫瘍

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中文摘要
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英文摘要
Photodynamic therapy (PDT) is expected as a new laser therapy for treating the oral cancer. However the machanisms of metastastatic effect when PDT is conducted is unknown. This study was conducted to clarify the machanisms of metastasis when PDT is conducted.Differentiated squamous cell carcinoma cell line (RSC3-E2) and undifferentiated tumor cell line (RSC3-LM) with different metastatic potential that established from a 4-nitroquinoline N-oxide (4NQO)-induced differentiated SCC in F344 rat were used for undergoing PDT using light (Wavelength 530〜540nm) and Photofrin^<TM> (hematoporphyrin derivative. Fibroblast cell line derived from mice was used as cntrol. Apoptosis indication was counted for estimating the metastatic influences. Apoptosis was not observed at RSC3-E2 and RSC3-LM cell lines when hematoporphyrin derivative was administered alone. However apoptosis was resisted at RSC3-E2 cell lines as well as control when PDT was underwent together with light source. These results suggested that metastasis would be promote on the conditions of PDT at this cell lines model.
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