Study for the Impact of Nuclear Factor-κB Expression in the radiosresitant Tumors

核因子-κB表达对放射抵抗肿瘤影响的研究

• 批准号: 23791426
• 负责人: YOSHIDA Kenji
• 金额: $ 2.58万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791426/
• 关键词: 放射線治療学; NF-Κb; NF-κB; 放射線抵抗性

We have analyzed the impact of NF-κB expression in the radioresistant tumors. In the immunohistochemistry for early stage laryngeal cancer, the rate of NF-κB expression in the recurrent group elevated significantlycomparing to that of non-recurrentgroup. Local control rate was also significantly worse in the NF-κB positive group comparing to that of the NF-κB negative group. Moreover, in the recurrent tumors, the rate of NF-κB expression elevated and the degree of NF-κB expression was enhanced. Therefore, NF-κB considered as a novel marker of radioresistance. In this study, we have been accumulating the specimens of cervical cancer, prostate cancer, and glioblastoma in addition to early stage laryngeal cancer and we are going to analyze the results from the study.

我们分析了NF-κB表达在放射耐药肿瘤中的影响。在早期喉癌的免疫组化中，复发组的NF-κB表达率明显高于未复发组。NF-κB阳性组的局部控制率也明显低于NF-κB阴性组。在复发肿瘤中，NF-κB表达率升高，表达程度增强。因此，NF-κB被认为是一种新的辐射耐药标志物。在这项研究中，除了早期喉癌，我们还积累了宫颈癌、前列腺癌、胶质母细胞瘤的标本，我们将对研究结果进行分析。

项目成果

Long-term outcome of hypofractionated radiotherapy to the whole breast of Japanese women after breast-conserving surgery.

日本女性保乳手术后全乳房大分割放疗的长期结果。

• DOI: 10.1007/s12282-012-0345-2
• 发表时间: 2014
• 期刊: Breast Cancer
• 影响因子: 4
• 作者: Ishihara T;Yoden E;Konishi K;Nagase N;Yoshida K;Kurebayashi J;Sonoo H;Murashima N;Sasaki R;Hiratsuka J
• 通讯作者: Hiratsuka J

Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index.

• DOI: 10.1186/1748-717x-7-104
• 发表时间: 2012-06-26
• 期刊: Radiation oncology (London, England)
• 作者: Uehara K;Sasayama T;Miyawaki D;Nishimura H;Yoshida K;Okamoto Y;Mukumoto N;Akasaka H;Nishihara M;Fujii O;Soejima T;Sugimura K;Kohmura E;Sasaki R
• 通讯作者: Sasaki R

LONG-TERM OUTCOME AND PATTERNS OF FAILURE IN PRIMARY OCULAR ADNEXAL MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMATREATED WITH RADIOTHERAPY

• DOI: 10.1016/j.ijrobp.2011.04.052
• 发表时间: 2012-03-15
• 期刊: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
• 影响因子: 7
• 作者: Hashimoto, Naoki;Sasaki, Ryohei;Sugimura, Kazuro
• 通讯作者: Sugimura, Kazuro

Radiotherapy for Japanese Elderly Patients with Cervical Cancer

日本老年宫颈癌患者的放射治疗

• 发表时间: 2013
• 作者: K Yoshida;D Miyawaki;H Nishimura;Y Ejima;K Nakabayashi;Y Ebina;R Sasaki
• 通讯作者: R Sasaki

Topics on Cervical Cancer With an Advocacy for Prevention

• DOI: 10.5772/1458
• 发表时间: 2012-03
• 作者: R. Rajkumar