Study for the Impact of Nuclear Factor-κB Expression in the radiosresitant Tumors

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We have analyzed the impact of NF-κB expression in the radioresistant tumors. In the immunohistochemistry for early stage laryngeal cancer, the rate of NF-κB expression in the recurrent group elevated significantlycomparing to that of non-recurrentgroup. Local control rate was also significantly worse in the NF-κB positive group comparing to that of the NF-κB negative group. Moreover, in the recurrent tumors, the rate of NF-κB expression elevated and the degree of NF-κB expression was enhanced. Therefore, NF-κB considered as a novel marker of radioresistance. In this study, we have been accumulating the specimens of cervical cancer, prostate cancer, and glioblastoma in addition to early stage laryngeal cancer and we are going to analyze the results from the study.