Analysis of Immnological Response in the Stomach of Suncus murinus against Newly Isolated Helicgbacter Species.

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In 1998, we isolated novel Helicobacter species from the stomach of all Suncus murinus (SUN line) maintained in our facility, and the isolates correlated with the presence of histologic lesions of chronic gastritis in the animals (Curr Microbiol 37 : 44-51, 1998). In this study, immunological response in the stomach of Suncus murinus to the Helicobacter species (Helicobacter suncus JM1459) was analysed.Gastritis was observed in stomachs of all Suncus murinus naturally and/or experimentally infected with H. suncus. The gastritis consisted of mononuclear cells but neutrophilia was not observed. Ten clones from the eDNA library constructed from stomachs with gastritis of Suncus murinus infected with H. suncus" were strongly expressed in stomachs with gastritis but not in stomachs without gastritis.Our results suggested that mononuclear cells play an important role in the host immune response in stomachs of Suncus murinus against Helicobacter species, and the gastritis related gene was obtained from the cDNA library constructed in this study. Clarification of details of immunological response in the stomachs of Suncus murinus requires analysis of the clones.