Development and regeneration of circadian clock
生物钟的发育和再生
基本信息
- 批准号:12640655
- 负责人:
- 金额:$ 2.05万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1. Temporal profiles of hatching in cricket (Gryllus bimaculatus) eggs incubated under different lighting regimens were examined. The results demonstrate that, by midembryogenesis, the embryonic circadian clock has been formed and is entrainable to 24-h light/dark cycles. In addition, the photoperiodic conditions to which the parents (probably the mothers) have been exposed influence the timing of egg hatching, suggesting that maternal factors regulate the timing of egg hatching.2. In the freshwater planarian Dugesia japonica, which belongs to most primitive metazoan phylum, serotonin was detected. Serotonin was localized in the cephalic ganglion (brain), in the main nerve cords extending posteriorly from the brain and in the commissure axons connecting the main nerve cords. The serotonin levels fluctuated with circadian rhythm, demonstrating the existence of a circadian timekeeping mechanism in planarian.3. To examine the effect of melatonin on in vitro fertilization and embryonic development, mouse embryos alter insemination in vitro were cultured in a physiological medium with or without melatonin. Melatonin increased the fertilization rate and the rate of early embryo development.4. The concentrations of noradrenaline in preovulatory follicular fluid obtained from women undergoing in vitro fertilization were determined and compared with those in peripheral plasma obtained currently. All of the follicular fluid samples contained noradrenaline at concentrations substantially higher than those in the corresponding plasma samples. A positive correlation was found between noradrenaline levels in follicular fluid and plasma in each woman. The data suggest that the main source of noradrenaline in the follicular fluid could be the general circulation.
1.研究了蟋蟀卵在不同光照条件下孵化的时间分布。结果表明,通过胚胎中期发生,胚胎昼夜节律钟已经形成,并能适应24小时的光/暗周期。此外,父母(可能是母亲)所暴露的光周期条件影响了卵孵化的时间,这表明母体因素调节了卵孵化的时间。在属于最原始后生动物门的淡水涡虫Dugesia japonica中检测到5-羟色胺。5-羟色胺位于头神经节(脑)、从脑向后延伸的主要神经索和连接主要神经索的连合轴突中。5-羟色胺水平随昼夜节律波动,表明涡虫存在昼夜计时机制.为了研究褪黑素对体外受精和胚胎发育的影响,将体外受精后的小鼠胚胎培养在含有或不含褪黑素的生理培养基中。褪黑素能提高受精率和早期胚胎发育率.本文测定了体外受精妇女排卵前卵泡液中去甲肾上腺素的浓度,并与目前获得的外周血浆中去甲肾上腺素的浓度进行了比较。所有卵泡液样本均含有浓度显著高于相应血浆样本的去甲肾上腺素。在每名妇女的卵泡液和血浆中去甲肾上腺素水平之间呈正相关。这些数据表明,卵泡液中去甲肾上腺素的主要来源可能是全身循环。
项目成果
期刊论文数量(26)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Murakami S., Itoh M.T.: "Effects of aggression and wing removal on brain serotonin levels in the male crickets, Gryllus bimaculatus"Journal of Insect Physiology. 47.1. 1309-1312 (2001)
Murakami S.,Itoh M.T.:“攻击和去除翅膀对雄性蟋蟀(Gryllus bimaculatus)大脑血清素水平的影响”昆虫生理学杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Itoh,M.T., Sumi,Y.: "Circadian clock controlling egg hatching in the cricket (Gryllusb bimaculatus)"J. Biol. Rhythms. 15. 241-245 (2000)
Itoh,M.T., Sumi,Y.:“控制蟋蟀 (Gryllusb bimaculatus) 卵孵化的昼夜节律时钟”J.
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Murakami, S., Itoh, M.T.: "Effects of aggression and wing removal on brain serotonin levels in the male crickets, Gryllus bimaculatus"Journal of Insect Physiology. 47.1. 1309-1312 (2001)
Murakami, S., Itoh, M.T.:“攻击和去除翅膀对雄性蟋蟀(Gryllus bimaculatus)大脑血清素水平的影响”昆虫生理学杂志。
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- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Itoh,M.T., Igarashi,J.: "Circadian rhythm of serotonin levels in planarians"Neuroreport. 11. 473-476 (2000)
Itoh,M.T.,Igarashi,J.:“涡虫血清素水平的昼夜节律”神经报告。
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- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Itoh,M.T., Murakami,S.: "Effect of female wings on male courtship behavior in the cricket Gryllus blmaculatus"Naturwissenshaften. (in press).
Itoh,M.T.,Murakami,S.:“雌性翅膀对蟋蟀 Gryllus blmaculatus 雄性求偶行为的影响”Naturwissenshaften。
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- 影响因子:0
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ITOH Masanori其他文献
ITOH Masanori的其他文献
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{{ truncateString('ITOH Masanori', 18)}}的其他基金
The synthesis and function of melatonin in the ovary
卵巢中褪黑激素的合成和功能
- 批准号:
22591839 - 财政年份:2010
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of brain controlling mechanism of sexual orientation
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17570054 - 财政年份:2005
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$ 2.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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