Transfer of egg probeins into breast milk

将卵探针转移至母乳中

• 批准号: 12660125
• 负责人: NARITA Hiroshi
• 金额: $ 2.3万
• 依托单位: Junior College of Kyoto Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12660125/
• 关键词: food allergy; allergen; egg; ovomucoid; breast milk; monoclonal antibody; immune complex; secretory IgA

On gel-filtration, the major food allergen, ovomucoid (28 kDa) in human breast milk was eluted only at the fractions corresponding to a molecular weight of about 450 kDa. Almost same elution profile as that for ovomucoid was obtained for its immune complex with sIgA. Similar results, suggesting the occurrence of food allergens as immune complexes with sIgAs have been also observed for other food allergens in breast milk. Relationship between the presence of allergens in mother's milk and allergic symptoms of their babies should be discussed hereafter in consideration of not only the level but also the molecular feature of allergens.

在凝胶过滤，主要的食物过敏原，卵类粘蛋白（28 kDa）在人母乳中洗脱，只有在对应于约450 kDa的分子量的馏分。卵类粘蛋白与sIgA的免疫复合物获得了与卵类粘蛋白几乎相同的洗脱曲线。类似的结果表明，食物过敏原作为免疫复合物与sIgA的发生也已观察到母乳中的其他食物过敏原。母乳中过敏原的存在与婴儿过敏症状之间的关系应在下文中讨论，不仅要考虑过敏原的水平，而且要考虑过敏原的分子特征。

项目成果

Junko HIROSE: "Occurrence of the major food allergen, ovomucoid, in human breast milk as an immune complex"Biosci. Biotechnol. Biochem.. 65(6). 1438-1440 (2001)

Junko HIROSE：“主要食物过敏原卵类粘蛋白作为免疫复合物出现在人母乳中”Biosci。

成田宏史: "母乳中の食物アレルゲンの分子形態"日本栄養・食糧学会誌. 55. 235-237 (2002)

Hiroshi Narita：“母乳中食物过敏原的分子形式”日本营养与食品科学学会杂志 55. 235-237 (2002)。

JUNKO HIROSE: "Occurrence of a major food allergen, ovomucoid, in human breast milk as an immune complex"Biosci.Biotechnol.Biochem.. (in press). (2001)

JUNKO HIROSE：“人类母乳中存在一种主要食物过敏原卵类粘蛋白作为免疫复合物”Biosci.Biotechnol.Biochem..（正在出版）。

Junko HIROSE: "Occurrence of the major food allergen, ovomucoid, in human breast milk as an immune complex"Biosci.Biotechnol.Biochem.. 65(6). 1438-1440 (2001)

Junko HIROSE：“人类母乳中主要食物过敏原卵类粘蛋白作为免疫复合物的出现”Biosci.Biotechnol.Biochem.. 65(6)。

Hiroshi NARITA: "Moleculor Features of Food Allergens in Human Breast Milk"J. Jpn. Soc. Nutr. Food Sci.. 55. 235-237 (2002)

成田浩：“人类母乳中食物过敏原的分子特征”J。