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A search for effective components of food flavor that stimulate energy expenditure and the analysis of its neuro-hormonal mechanism

刺激能量消耗的食品风味有效成分的寻找及其神经激素机制分析

基本信息

批准号：
12660123
负责人：
SHIMAZU Takashi
金额：
$ 2.37万
依托单位：
Hiroshima Jogakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2003
项目状态：
已结题

项目摘要

The object of this study was to (1)explore and identify effective components of food flavor that stimulates energy expenditure in the body, and (2)to elucidate the actions of centrally-acting neuropeptides that regulate food intake on energy expenditure by analyzing whole-body oxygen consumption (VO2) and the respiratory quotient(RQ).1.On the first category of the studies, we examined the effects of ginger and raspberry and their effective components, zingerone and raspberry ketone, on VO2 and RQ in rats fed a high-carbohydrate diet or a high-fat(lard) diet. Addition of 2% ginger powder or 0.4% zingerone to both diets caused significant increase in 12-h cumulative VO2 during the dark(feeding) period. The RQ value during the period was reduced significantly by the addition of ginger or zingerone. Similarly, addition of 0.4〜5% raspberry ketone to the both diets caused dose-dependent increases in the cumulative VO2 and decreases in the RQ values. In addition, addition of raspberry ketone to the high-fat diet prevented the accumulation of triglycerides in adipose tissues and liver, and amended disorder of lipid metabolism induced in rats fed the high-fat diet for 4 weeks.2.Among orexigenic substances, orexin-A administered into the third ventricle of rats caused a marked increase in VO2, but conversely noradrenaline(NA) decreased VO2. transiently Intracerebroventricular microinjection of neuropeptide Y and ghrelin increased the RQ values, but NA caused transient decrease in the RQ. However, central injection of galanin, orexin-B, or melanin-concentrating hormone did not affect both the VO2 and RQ values significantly.Among anorexigenic neuropeptides, on the other hand, leptin caused a decrease in RQ but did not affect significantly the cumulative VO2 during the dark period By contrast, microinjection of corticotropin-releasing hormone was found to reduce RQ and increase the cumulative VO2.

本研究的目的是（1）探索和识别刺激体内能量消耗的食品风味的有效成分，以及（2）通过分析全身耗氧量（VO2）和呼吸商（RQ）来阐明调节食物摄入对能量消耗的中枢作用神经肽的作用。1.在第一类研究中，我们检查了生姜和覆盆子的影响其有效成分姜油酮和覆盆子酮对高碳水化合物饮食或高脂肪（猪油）饮食的大鼠的摄氧量和RQ的影响。在两种日粮中添加 2% 生姜粉或 0.4% 姜油酮都会导致黑暗（喂养）期间 12 小时累积摄氧量显着增加。期间RQ值因生姜或姜油酮的添加而显着降低。同样，在两种日粮中添加 0.4〜5% 覆盆子酮都会导致累积 VO2 呈剂量依赖性增加，而 RQ 值则呈剂量依赖性下降。此外，在高脂饮食中添加覆盆子酮可防止脂肪组织和肝脏中甘油三酯的积累，并改善高脂饮食4周引起的大鼠脂质代谢紊乱。 2.在促食欲物质中，向大鼠第三脑室注射食欲素-A可显着增加VO2，但相反，去甲肾上腺素(NA)会降低VO2。脑室内短暂注射神经肽 Y 和 ghrelin 会增加 RQ 值，但 NA 会导致 RQ 短暂下降。然而，中枢注射甘丙肽、食欲素-B或黑色素浓缩激素并没有显着影响VO2和RQ值。另一方面，在厌食神经肽中，瘦素导致RQ降低，但不会显着影响黑暗期的累积VO2。相比之下，微量注射促肾上腺皮质激素释放激素被发现会降低RQ并增加RQ值。累积摄氧量。