ISS MetaOx Tissue Oxygen Consumption Monitor

ISS MetaOx 组织耗氧量监测仪

• 批准号: 10175201
• 负责人: Michael Douglas Nelson
• 金额: $ 24.81万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175201
• 关键词: Address; Area; Blood flow; Cerebrum; Computer software; Core Facility; Devices; Diffuse; Doppler Ultrasound; Extramural Activities; Faculty; Frequencies; Funding; Hemoglobin; Infrastructure; Lasers; Magnetic Resonance Imaging; Measurement; Metabolism; Microspheres; Monitor; Muscle; Near-Infrared Spectroscopy; Organ; Oxygen; Oxygen Consumption; Perfusion; Physiologic pulse; Regulation; Research; Research Project Grants; Skeletal Muscle; Spectrum Analysis; Spin Labels; System; Techniques; Tissues; Xenon; college; design; instrument; member; multidisciplinary; temporal measurement; tool; user-friendly

Project Summary/Abstract Diffuse Correlation Spectroscopy (DCS) is a powerful new tool to assess cerebral and skeletal muscle microvascular perfusion. DCS is completely noninvasive, has excellent temporal resolution, and has been validated in a variety of organs and tissues, against several different standards, including laser Doppler , Xenon- CT, fluorescent microsphere flow measurements, arterial spin labelled-MRI, and pulse-wave Doppler ultrasound. Combining DCS with conventional near-infrared spectroscopy (NIRS)—an established technique for characterizing the transport and utilization of oxygen—introduces exciting new possibilities for understanding the determinants of cerebral and muscle oxygen utilization, at the microvascular level. The specific aim of this application is to acquire an ISS MetaOx Tissue Oxygen Consumption Monitor – currently the only commercially available DCS device on the market. This instrument is well suited for a multidisciplinary core facility due to its user-friendly integrated software, and robust analysis features. It address all of the limitations currently associated with our current NIRS/DCS systems, including quantitative measurement of hemoglobin concentration using Frequency-Domain Near-Infrared Spectroscopy. Moreover, its cross-organ versatility extends its research application beyond cerebral oxygen metabolism—for which it was originally designed for— allowing UTA faculty to also assess the determinants of skeletal muscle oxygen metabolism and skeletal muscle blood flow regulation; an area of research that UTA faculty are actively involved in. The MetaOx will significantly enhance the research and educational infrastructure of UTA, and will stimulate collaborative research projects between a large group of extramurally funded faculty members, spanning multiple Colleges and many Departments across campus.

项目总结/摘要 弥散相关光谱（DCS）是一种强大的新工具，以评估大脑和骨骼肌 微血管灌注DCS是完全非侵入性的，具有出色的时间分辨率， 在各种器官和组织中进行了验证，针对几种不同的标准，包括激光多普勒，氙气， CT、荧光微球流量测量、动脉自旋标记MRI和脉冲波多普勒超声。 将DCS与传统的近红外光谱（NIRS）相结合-一种用于检测 描述氧气的运输和利用，介绍了令人兴奋的新的可能性，了解 脑和肌肉氧利用的决定因素，在微血管水平。其具体目的是 应用程序是获得ISS MetaOx组织耗氧量监测仪-目前唯一的商业 市场上现有的DCS设备。该仪器非常适合多学科核心设施，因为它 用户友好的集成软件和强大的分析功能。它解决了目前所有的限制 与我们目前的NIRS/DCS系统相关，包括血红蛋白的定量测量 使用频域近红外光谱法测定浓度。此外，它的跨器官功能 将其研究应用扩展到脑氧代谢之外--它最初是为脑氧代谢而设计的-- 允许UTA教师也评估骨骼肌氧代谢和骨骼肌的决定因素， 血流调节; UTA教师积极参与的研究领域。MetaOx将显著 加强UTA的研究和教育基础设施，并将促进合作研究项目 大量校外资助的教职员工之间，跨越多个学院和许多 整个校园的各个部门。

项目成果

DCS blood flow index underestimates skeletal muscle perfusion in vivo: rationale and early evidence for the NIRS-DCS perfusion index.

DCS 血流指数低估了体内骨骼肌灌注：NIRS-DCS 灌注指数的基本原理和早期证据。

• DOI: 10.1117/1.jbo.29.2.020501
• 发表时间: 2024
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: Bartlett,MilesF;Oneglia,AndrewP;Ricard,MarkD;Siddiqui,Ashfaq;Englund,ErinK;Buckley,ErinM;Hueber,DennisM;Nelson,MichaelD
• 通讯作者: Nelson,MichaelD