ISS MetaOx Tissue Oxygen Consumption Monitor

项目摘要/摘要 漫相关光谱分析是一种新的脑和骨骼肌研究工具 微血管灌流。分布式控制系统是完全非侵入性的，具有出色的时间分辨率，并已被 在各种器官和组织中进行验证，对照几个不同的标准，包括激光多普勒、氙气- CT、荧光微球血流测量、动脉自旋标记MRI和脉搏波多普勒超声。 将分布式控制系统与常规近红外光谱(NIRS)相结合-这是一种成熟的技术 氧的运输和利用的特征-为理解氧的运输和利用引入了令人兴奋的新可能性 在微血管水平上，大脑和肌肉氧气利用的决定因素。这样做的具体目的是 申请收购ISS MetaOx组织氧耗监测器-目前唯一商业化的 市场上有可用的集散控制系统设备。该仪器非常适合于多学科核心设施，因为它 用户友好的集成软件和强大的分析功能。它解决了目前所有的限制 与我们当前的近红外光谱/分布式控制系统相关，包括对血红蛋白的定量测量 利用频域近红外光谱进行浓缩。此外，它的跨器官多功能性 将其研究应用扩展到脑氧代谢--这是它最初设计的目的- 允许UTA教员也评估骨骼肌氧代谢和骨骼肌的决定因素 血流调节；UTA教职员工积极参与的研究领域。MetaOx将显著 加强UTA的研究和教育基础设施，并将鼓励合作研究项目 在一大群校外资助的教职员工之间，他们跨越多所学院和许多 校园里的各个部门。

Project Summary/Abstract Diffuse Correlation Spectroscopy (DCS) is a powerful new tool to assess cerebral and skeletal muscle microvascular perfusion. DCS is completely noninvasive, has excellent temporal resolution, and has been validated in a variety of organs and tissues, against several different standards, including laser Doppler , Xenon- CT, fluorescent microsphere flow measurements, arterial spin labelled-MRI, and pulse-wave Doppler ultrasound. Combining DCS with conventional near-infrared spectroscopy (NIRS)—an established technique for characterizing the transport and utilization of oxygen—introduces exciting new possibilities for understanding the determinants of cerebral and muscle oxygen utilization, at the microvascular level. The specific aim of this application is to acquire an ISS MetaOx Tissue Oxygen Consumption Monitor – currently the only commercially available DCS device on the market. This instrument is well suited for a multidisciplinary core facility due to its user-friendly integrated software, and robust analysis features. It address all of the limitations currently associated with our current NIRS/DCS systems, including quantitative measurement of hemoglobin concentration using Frequency-Domain Near-Infrared Spectroscopy. Moreover, its cross-organ versatility extends its research application beyond cerebral oxygen metabolism—for which it was originally designed for— allowing UTA faculty to also assess the determinants of skeletal muscle oxygen metabolism and skeletal muscle blood flow regulation; an area of research that UTA faculty are actively involved in. The MetaOx will significantly enhance the research and educational infrastructure of UTA, and will stimulate collaborative research projects between a large group of extramurally funded faculty members, spanning multiple Colleges and many Departments across campus.