Industrial biotechnology for the manufacture of alkaloid pharmaceuticals

治疗阿片类药物依赖和过量的药物越来越需要，但它们的制造困难、效率低下和昂贵。该项目旨在开发酶促N-脱甲基化，作为制造和修饰阿片类拮抗剂、生物碱和其他药物靶标的一种更简单、更可持续的方法。它将增加我们对酶促N-脱甲基化的理解，并解决工程和生物技术方面的挑战，以提高产量和产品分离和浓缩。药品制造流程的改进将有助于受影响的药品社区和行业将受益于增值、更大的市场份额和灵活性、更多的创新以及降低流程和新产品的风险。

Drugs that treat opioid dependence and overdose are increasingly needed but their manufacture is difficult, inefficient and expensive. This project aims to develop enzymatic N-demethylation as a simpler and more sustainable approach to the manufacture and modification of opioid antagonists, alkaloids and other drug targets. It will increase our understanding of enzymatic N-demethylation and address engineering and biotechnology challenges to improve yield and product isolation and concentration. Improvements in drug manufacturing processes will assist drug affected communities and industry will benefit from value adding, greater market share and flexibility, increased innovation and de-risked processes and new products.