STUDY ON THE EFFECTS OF CO-PLANAR PCBS ON THE FUNCTION AND MORPHOLOGY OF FEMALE GENITAL ORGANS

在实验中（Exp.）。一、雌性SD大鼠，每天口服玉米油或3，3 '，4，4'，5-五氯联苯（PCB 126）（共面PCB的同系物），剂量分别为1和3 μg/kg/天，持续2周，然后交配并受孕。持续每日给药，直至分娩后20天。暴露于PCB 126延迟阴道开口（VO），并减少了3 μg/kg/天剂量下首次排卵时排出的卵母细胞数量。在Exp.在妊娠第15天（GD 15），雌性SD大鼠单次口服玉米油或10和100 μg/kg的PCB 126。向母鼠单次注射10或100 μg/kg的PCB 126可显著延迟VO并减少其后代首次排卵时排出的卵母细胞数量。在实验中，大多数后代暴露于100 μg/kg。II显示VO与这些后代的第一次排卵不同步，排卵时子宫重量减少。在两个实验中。I和II，暴露的雌性后代显示尿道下裂。在Exp. III.妊娠雌性SD大鼠在GD 8或GD 15单次经口给予玉米油或1和10 μg/kg PCB 126。在暴露于10 μg/kg的雌性后代中诱导尿道下裂。在另外的实验中，表明哺乳期暴露于PCB 126不会诱发雌性后代尿道下裂。在GD 15暴露于10 μg/kg PCB 126的雌性后代在20周龄和30周龄时表现出持续发情和卵巢重量减少。

In experiment (Exp.).I, female SD rats copulated and conceived after daily oral administration for 2 weeks of either corn oil or 1 and 3 μg/kg/day of 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB 126), a congener of coplanar PCBs, respectively. Daily administration was continued until 20 days alter delivery through the gestational period. Exposure to PCB 126 delayed vaginal opening (VO) and reduced the number of oocytes shed at first ovulation at a dose of 3 μg/kg/day. In Exp. II, pregnant female SD rats were single-administered orally either corn oil or 10 and 100 μg/kg of PCB 126 on gestational day 15 (GD 15). A single injection of 10 or 100 μg/kg of PCB 126 to the dams delayed VO and reduced the number of oocytes shed at the first ovulation in their offspring significantly. Most offspring exposed to 100 μg/kg in Exp. II showed VO unsynchronized with the first ovulation in these offspring and reduced uterine weight at the ovulation. In both Exps. I and II, exposed female offspring showed hypospadias. In Exp. III, pregnant female SD rats were single-administered orally either corn oil or 1 and 10 μg/kg of PCB 126 on GD 8 or GD15. Hypospadias was induced in the female offspring exposed to 10 μg/kg. In additional experiment indicate d that lactational exposure to PCB 126 did not induce hypospadias in female offspring. Female offspring exposed to 10 μg/kg of PCB 126 on GD15 showed continuous estrus and reduced ovarian weight at 20 weeks and 30 weeks of age.