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Novel recognition methods for environmental hormones based on spatial multi-points interaction

基于空间多点交互的环境激素识别新方法

基本信息

批准号：
11640608
负责人：
HOSOYA Ken
金额：
$ 2.18万
依托单位：
Kyoto Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11640608/
关键词：
Molecular imprinting Separation media Molecular recognition Environmental hormone Bisphenol A HPLC Environmental Science Toxic compound 分子メディア分子認識

项目摘要

Porogen imprinting effectPorogen imprinting effect can utilize the template molecule having similar structure to the real target molecule. The detail study revels that the polymer prepared through porogen imprinting effect tends to recognize relatively bulky molecule that can be hardly recognized through traditional molecular imprinting effect. Usually, environmental hormones has rather structurally bulky structure, therefore the porogen imprinting effect is quite useful for the recognition of those compounds. In addition, the molecule which is a part of larger molecule, such as oligopeptides and/or polymers can be utilized as "Fragment template" to realize selective molecular recognition to large molecules.Molecular imprinting toward Bisphenol ABisphenol A known as an environmental hormone can be utilized as the template molecule for traditional molecular imprinting technique with vinyl pyridine or vinyl imidazole as a functional monomer, but t-butyl phenol can be also utilized as a template molecule toward bisphenol A.In fact, those polymer prepared using t-butyl phenol as template molecule can be afford even higher selectivity to bisphenol A compared with those prepared bisphenol A as the template molecule. The obtained absorption ability is even comparable to that of activated carbons.New separation media and those propertiesWe have prepared uniformly sized polymer particles using new membrane emulsification technique as well as porous monolith type separation media (rod column) to investigate those separation properties as well as possibility as absorbents for our purpose. In the result, size uniformity is quite important for the treatment of environmental aqueous solution. In addition, rod column afford possible ultra high column efficiency in capillary electorochromatograh

致孔剂印迹效应致孔剂印迹效应可以利用与真实的目标分子具有相似结构的模板分子。详细的研究表明，通过致孔剂印迹效应制备的聚合物倾向于识别传统分子印迹效应难以识别的相对较大的分子。通常，环境激素具有相当大的结构体积，因此致孔剂印迹效应对于这些化合物的识别是非常有用的。此外，作为大分子一部分的分子，如寡肽和/或聚合物，可以作为“片段模板”，实现对大分子的选择性分子识别，对环境激素双酚A的分子印迹可以作为以乙烯基吡啶或乙烯基咪唑为功能单体的传统分子印迹技术的模板分子，但叔丁基苯酚也可以用作双酚A的模板分子。事实上，与双酚A作为模板分子制备的聚合物相比，使用叔丁基苯酚作为模板分子制备的聚合物可以提供甚至更高的双酚A选择性。新的分离介质和这些性能我们已经使用新的膜乳化技术以及多孔整体型分离介质（棒柱）制备了均匀尺寸的聚合物颗粒，以研究这些分离性能以及作为吸附剂用于我们目的的可能性。结果表明，粒径均匀性对环境水溶液的处理是非常重要的。此外，棒状柱在毛细管电色谱中提供了超高柱效的可能