A historical cohort on the risk of death from cancer in forestry workers possibly exposed to dioxin from spraying weeds

关于可能因喷洒杂草而接触二恶英的林业工人癌症死亡风险的历史队列

• 批准号: 12670326
• 负责人: KURUMATANI Norio
• 金额: $ 2.18万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670326/
• 关键词: Herbicide; Forestry workers; Historical cohortstudy; Cause of death; Dioxins

This study aimed to clarify the influence of dioxin on health, particularly the degree of risk of death from cancer, by tracking a group of national forestry workers who may have been exposed to dioxin.Of 2266 national forestry workers identified from several name lists, 2091 workers whose addresses were also available were listed as members of the cohort. It was ascertained whether these workers were alive or dead. In the cases of death, permission from the Ministry of Justice was obtained to examine the death certificate or death registration certificate. After determining the primary cause of death according to the International Classification of Diseases (ICD), estimation of whether or not there were excessive deaths was made based on the Standardized Mortality Ratio (SMR) at the 95% confidence interval.Of the 966 male workers assumed to have been exposed by spraying a weed killer containing 2, 4, 5 - T, 224 workers had died in the period from 1978 (when tracking was started) to 20 … More 02. Analysis of the total deaths of these male workers produced an SMR of 0.69 (95% confidence interval: 0.6 1 -0.79), which was significantly lower than the national average. Death due to cardiac disease was 0.58 (0.39-0.85), and death due to cerebral vascular accident was 0.58 (0.37-0.85), with the SMR being significantly lower than 1 in both cases. Of the 192 female forestry workers, 16 had died. The SMR of total deaths in this group was 0.43 (0.26-0.69), which was significantly lower than the national average. Although the confidence interval was large, because few subjects died from cardiac disease or cerebral vascular accident, the point estimation value was less than 1. These results include those for 64 workers in seedling fields, which were the same as the results for the male workers. It was thought that these results suggested an effect of healthy workers.The SMR for all malignant tumors as the cause of death for male forestry workers was 0.70 (0.56-0.86), for female forestry workers it was 0.78 (0.41-1.42) and for female workers in the seedling fields it was 1.42 (0.67-2.9 1 ). These values are lower than the national average. No significantly increased deaths of site-specific cancers were observed in both sexes.The death rate for all subjects in the time period analyzed remained at around 20%. Therefore, we believe that it is necessary to follow the subjects for a longer period in order to obtain a definite conclusion. Less

本研究以可能接触过二恶英的国家林业工作人员为对象，从2266名国家林业工作人员中，将2091名有地址的工作人员列为队列成员，以明确二恶英对健康的影响，特别是癌症死亡的危险程度。这些工人是死是活已查明。在死亡的情况下，要获得司法部的许可，才能检查死亡证明或死亡登记证明。在根据国际疾病分类（ICD）确定主要死因后，根据95%置信区间的标准化死亡率（SMR）估计是否有过量死亡。在966名假定接触含2，4，5 - T除草剂的男性工人中，从1978年（开始跟踪）到20年， ...更多信息 02.对这些男性工人死亡总数的分析得出SMR为0.69（95%置信区间：0.61 - 0.79），显著低于全国平均水平。心脏病死亡率为0.58（0.39-0.85），脑血管意外死亡率为0.58（0.37-0.85），两例患者的SMR均显著低于1。在192名林业女工中，有16人死亡。该人群总死亡的SMR为0.43（0.26-0.69），明显低于全国平均水平。尽管置信区间较大，但由于很少受试者死于心脏病或脑血管意外，因此点估计值小于1。这些结果包括64名育苗工人，其结果与男性工人相同。所有恶性肿瘤死亡的SMR，男性林业工人为0.70（0.56-0.86），女性林业工人为0.78（0.41-1.42），育苗场女工为1.42（0.67 ~ 2.91）。这些数值低于全国平均水平。在两种性别中均未观察到部位特异性癌症的死亡率显著增加。在分析的时间段内，所有受试者的死亡率保持在20%左右。因此，我们认为有必要对这些问题进行更长时间的跟踪，以获得明确的结论。少