Validation of asbestos exposure in mesothelioma cases clustered among residents near an asbestos cement pipe production factory and risk estimation of deaths due to mesothelioma.

验证石棉水泥管生产工厂附近居民间皮瘤病例中石棉暴露的情况，并对间皮瘤造成的死亡风险进行评估。

• 批准号: 18590567
• 负责人: KURUMATANI Norio
• 金额: $ 2.5万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590567/
• 关键词: Asbestos exposure; Mesothelioma; Neighborhood exposure; Risk of mortality; Pathological diagnosis; Radiographic diagnosis

We obtained pleural tissue having mesothelioma, intact lung tissue or chest CT films from 72 mesothelioma cases or their families, who granted our interview study and gave a written informed consent. All cases were residents who had lived near an asbestos cement pipe production plant, Kubota. Pleural tissues were provided for re-examination for pathological diagnosis using an immunostaining assay, which consisted of both positive makers for mesothelioma and negative ones for lung cancer. Of 31 cases whose diagnosis was mesothelioma, only one case (3.0%) turned out to be a different disease by re-examination of the tissue. Three radiographic specialists agreed that all films fad findings consistent with those commonly observed in mesothelioma cases. They indicated an existence of pleural plaque in 23.7% of the study subjects. The number of asbestos bodies in the lung tissue was successfully counted in 12 subjects. Half of them showed the number which was much lower than that of workers exposed to asbestos occupationally but higher than in persons not exposed to asbestos of any kind. Asbestos fiber concentrations in the lung could be counted in five subjects. Fibers of crocidolite were found in all study subjects. However, we could not obtain definite conclusions because these subjects were likely to be exposed occupationally or domestically.These results suggest that misdiagnosis is much lower than we had imagined and neighborhood exposure to asbestos occurred among residents near the plant. Of 178 residents with asbestos-related diseases with whom we made an interview, 73, who lived in the area within 1, 500 meters from the plant, died from mesothelioma after Jan, 1, 1995 till the end of 2006. SMRs of mesothelioma increased significantly as high as 14 among men and 41 among women within 300 meters. A significant elevation of SMRs in women extended as far as 1, 500 meters way from the plant.

我们从72例间皮瘤患者或其家属中获得了间皮瘤的胸膜组织、完整的肺组织或胸部CT片，他们同意我们的访谈研究并提供了书面知情同意书。所有病例都是居住在久保田石棉水泥管道生产厂附近的居民。提供胸膜组织用于使用免疫染色测定法进行病理诊断的复检，所述免疫染色测定法包括间皮瘤的阳性标记物和肺癌的阴性标记物。31例诊断为间皮瘤的病例中，只有1例（3.0%）经组织复查发现为不同疾病。三位放射学专家一致认为，所有的电影fad发现与间皮瘤病例中常见的一致。他们指出23.7%的研究受试者存在胸膜斑块。12例肺组织中石棉小体计数成功。他们中的一半显示的数字远低于职业接触石棉的工人，但高于没有接触任何种类的石棉的人。肺中的天冬氨酸纤维浓度可以在5名受试者中计数。青石棉纤维被发现在所有的研究对象。然而，我们不能得到明确的结论，因为这些受试者可能是职业暴露或家庭。这些结果表明，误诊率比我们想象的要低得多，并在工厂附近的居民中发生邻居接触石棉。1995年1月1日至2006年底，在我们采访的178名石棉相关疾病居民中，73人死于间皮瘤，他们居住在距离工厂1500米以内的地区。间皮瘤的SMR显著增加，在300米范围内，男性高达14，女性高达41。在离核电站1500米远的地方，妇女的SMR显著升高。

项目成果

アスベストの近隣ばく露による中皮腫の疫学

邻里接触石棉所致间皮瘤的流行病学

• 发表时间: 2007
• 期刊: 最新医学 62
• 作者: Yamada Y;Kato K;Yoshida T;Yokoi K;Matsuo H;Watanabe S;Ichihara S;Metoki N;Yoshida H;Satoh K;Aovagi Y;Yasunaga A;Park H;Tanaka M;Nozawa Y.;車谷 典男・熊谷 信二
• 通讯作者: 車谷 典男・熊谷 信二

クボタ旧石綿管工場駿ヘンにおける中皮腫の疫学評価

久保田原石棉管厂舜恒间皮瘤流行病学评估

• 发表时间: 2006
• 期刊: 労働の科学 61
• 作者: 熊谷信二;車谷典男
• 通讯作者: 車谷典男

アスベスト問題のアップデート(教育講演)

石棉问题的最新情况（教育讲座）

• 发表时间: 2007
• 作者: 市原佐保子;横田充弘;車谷 典男・熊谷 信二;車谷 典男
• 通讯作者: 車谷 典男

石綿の近隣曝露と中皮腫罹患リスク

邻里接触石棉和患间皮瘤的风险

• 发表时间: 2007
• 期刊: 産業衛生学雑誌 49
• 作者: Yamada Y;Kato K;Oguri M;Fujimaki T;Yokoi K;Matsuo H;Watanabe S;Metoki N;Yoshida H;Satoh K;Ichihara S;Aoyagi Y;Yasunaga A;Park H;Tanaka M;Nozawa Y.;熊谷 信二・車谷 典男
• 通讯作者: 熊谷 信二・車谷 典男

Health hazards caused by asbestos of an asbestos cement pipe production company ; epidemiological studies from Italy(in Japanese)

石棉水泥管生产企业石棉对健康的危害；

• 发表时间: 2007
• 期刊: Rodo no Kagaku 62
• 作者: Kumagai S;Kurumatani;N
• 通讯作者: N