A historical cohort study of carpenters exposed to low dose asbestos in a shipyard

对造船厂中接触低剂量石棉的木匠进行的历史队列研究

• 批准号: 09670408
• 负责人: KURUMATANI Norio
• 金额: $ 1.28万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670408/
• 关键词: Historical cohort study; Asbestos; Arsenic; Lung cancer; Malignant mesothelioma; Refiners; shipyard workers; 石綿曝露; 砒素曝露; 職業性石綿曝露; 歴史的コ-ホ-ト研究; 標準化死亡比; 過剰死亡

Two historical cohort studies were conducted to investigate the effect of low dose asbestos exposure on mortality in occupational settings. One cohort consisted of 153 male carpenters worked as of 1976 in a shipyard. They had been exposed to asbestos intermittently for a short period when building rooms in a ship. The other cohort enrolled 199 workers (140 males and 59 females) in an arsenopyrite mine employed at some time between 1946 and 1958, the cohort which was set for a 'positive' control group to compare the magnitude of carcinogenecity between asbestos and arsenic. The carpenters were followed from 1976 to May 31, 1999 and 145 of the 153 study subjects were identified. 20 of them had died. The SMR of overall deaths, adjusted to the mortality in 5-year age and calendar year in a 5-year period in general Japanese populations, was 1.2, whose 95 % confidence interval included the null value. Three carpenters died from malignant mesothelioma. Other causes of death, including lung ca … More ncer, did not show increased SMRs, however. These results contrasted with those among the laggers exposed to asbestos much higher than the carpenters in our previous study. The laggers showed an increased SMR of 3.2 of lung cancer but no death from mesothelioma. The miners were followed from the date of employment till Dec 31, 1998. A total of 127 of 140 males and 55 of 57 females were successfully identified. 77 males had died. Of them 11 died form lung cancer. Subcohort analysis by job revealed that eight of 34 refiners in a mine died form the cancer and this occurrence corresponded to the SMR of 19 (99 % C.I. : 6.9-44.9). The refiners refined arsenopyrite ores and collected powdered arsenic, and accordingly were exposed arsenic heavily for five years in average. No elevated SMRs of any diseases were obtained in the female workers. The present results indicated that asbestos might have a lower carcinogenecity for lung cancer compared with arsenic, and that low dose exposure of asbestos could develop malignant mesothelioma rather than lung cancer. Less

进行了两项历史队列研究，以调查低剂量石棉暴露对职业环境中死亡率的影响。其中一组由153名1976年在造船厂工作的男性木匠组成。他们在船上建造房间时，曾在短时间内间歇性地接触过石棉。另一组在1946年至1958年间的某段时间招募了在毒砂矿工作的199名工人（140名男性和59名女性），该队列被设置为“阳性”对照组，以比较石棉和砷之间的致癌性程度。从1976年到1999年5月31日，研究人员对木匠进行了跟踪调查，153名研究对象中有145人被确定。其中20人已经死亡。总体死亡的SMR，调整为5岁年龄和5年期间日本一般人群的历年死亡率，为1.2，其95%置信区间包括零值。三个木匠死于恶性间皮瘤。然而，其他死因，包括肺癌和肺癌，并没有显示出smr的增加。这些结果与我们之前研究中暴露于石棉的工人的结果形成了对比，这些工人的石棉暴露率远高于木匠。laggers显示肺癌的SMR增加了3.2，但没有间皮瘤死亡。这些矿工从受雇之日起一直被跟踪到1998年12月31日。140只雄性中有127只，57只雌性中有55只。77名男性死亡。其中11人死于肺癌。job的亚队列分析显示，该矿34名精炼厂中有8人死于癌症，这一发生率对应的SMR为19 （99% ci: 6.9-44.9）。精炼厂对毒砂矿石进行精炼，并收集粉状砷，平均暴露于重度砷环境5年。在女工中未发现任何疾病的smr升高。本研究结果表明，与砷相比，石棉对肺癌的致癌性可能较低，低剂量接触石棉可诱发恶性间皮瘤而非肺癌。少

项目成果

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Makoto Yamamoto 等人：“砷矿山工人的跟踪调查（第一份报告）”工业卫生杂志（1999 年）。

Yamamoto, M., Kurumatani, N..et al: "A follow-up study of workers in an arsenopyrite mine. I.Working conditions and a reports of cases died from lung cancer" Sangyo Eiseigaku Zasshi. (in press). (1999)

Yamamoto, M., Kurumatani, N..等人：“毒砂矿工人的后续研究。I.工作条件和死于肺癌的病例报告”Sangyo Eiseigaku Zasshi。

車谷 典男 ほか: "砒素鉱山労働者の追跡調査 (第2報)" 産業衛生学雑誌. (印刷中). (1999)

Norio Kurumatani 等人：“砷矿山工人的跟踪调查（第二次报告）”《工业卫生杂志》（出版中）。