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Study on the biological effects of the environmental arsenic expo-sure

环境砷暴露的生物学效应研究

基本信息

批准号：
12670336
负责人：
CHIBA Keiko
金额：
$ 2.05万
依托单位：
Morioka Junior College, Iwate Prefectural University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670336/
关键词：
inorganic arsenic chronic arsenic poisoning oxidative stress DNA damage marine product hot spring water 8-hydroxydeoxyguanosine biological monitoring 海藻類発癌リスク海藻類摂取

项目摘要

Arsenic occurs in marine products, such as fish, shellfish and seaweed and also occurs in hot spring water. To evaluate the biological effects of these environmental arsenic exposures, we proposed to examine the urinary concentrations of arsenic species in 3 groups, a)Japanese ordinary healthy people, b)peosons who eat much marine products, c)persons who daily use the hot spring water. Inorganic arsenic(iAs), monomethyl arsenic(MA), dimethyl arsenic(DMA) and trimethyl arsenic(TMA) were detected in urine of healthy people and it was composed 70% more by TMA. IMD level that indicated as the sum of iAs and its metabolites (MA and DMA) was a useful marker of inorganic arsenic poisoning. Because higher levels of urinary IMD were detected in many healthy people who were not suffered from arsenic exposure, we have to consider its meaning in the future. Urinary arsenic levels of all species, especially DMA and TMA were significantly higher in the persons who eat much marine products than healthy people. It was suggested that much intake of marine products reflected on this result. To evaluate the role of oxidative stress in environmental arsenic and to establish the biological monitoring for arsenic, urinary 8-hydroxydeoxyguanosine(8-0HdG) levels of all persons in 3 groups were measured. Neither sex nor age differences were found in urinary 8-0HdG levels of healthy people. 8-0HdG levels in both persons who eat much marine products and who daily use the hot spring water were significantly higher than healthy people. However no significant correlation was shown between the urinary concentrations of arsenic species and 8-0HdG levels, such high level of 8-0HdG in 2 groups was suggested due to the environmental arsenic exposure.

砷存在于鱼类、贝类和海藻等海产品中，也存在于温泉水中。为了评估这些环境砷暴露的生物学效应，我们建议检测3组人群(a)日本普通健康人，b)食用大量海产品的人，c)每天使用温泉水的人的尿液中砷种的浓度。健康人群尿液中检出无机砷（iAs）、单甲基砷（MA）、二甲基砷（DMA）和三甲基砷（TMA），其中以TMA含量高70%。以无机砷及其代谢产物（MA和DMA）的总和表示的IMD水平是无机砷中毒的有用标志。由于在许多未遭受砷暴露的健康人群中检测到较高水平的尿IMD，我们必须在未来考虑其意义。食用大量海产品的人尿液中所有种类的砷含量，特别是DMA和TMA含量明显高于健康人。有人认为，大量摄入海产品反映了这一结果。为评价氧化应激在环境砷中的作用，建立砷的生物监测方法，测定3组患者尿8-羟基脱氧鸟苷（8-0HdG）水平。健康人群尿中8-0HdG水平没有性别和年龄差异。食用大量海产品和每天饮用温泉水的人的8-0HdG水平均显著高于健康人。但尿中砷种浓度与8-0HdG水平无显著相关性，提示两组患者出现如此高的8-0HdG水平与环境砷暴露有关。