Research on the improvement of the chronic arsenic poisoning in China

在内蒙古和山西进行了慢性砷中毒的防治试验。对于慢性砷中毒患者，尤其是本研究中，角化过度是否能够因为砷暴露量的减少而得到改善，这一点得到了验证。调查对象为内蒙古包头市某村民，该村人口430户，2080人。村民以农业和畜牧业为生，家庭生活和饮食习惯几乎相同。村民选出96人，皮肤科医生对其进行了检查。测定了尿中砷和8- OHdG浓度。为减少患者的无机砷暴露，提供了中国饮用水中砷含量低于0.05ppm的标准值。这井水（管式供水）是用来烧水和做饭的。通过改善井水，病人的砷暴露量已减少到原来的一半左右。人们认为，由于无机砷暴露的减少，氧化DNA损伤得到了改善，这一结果有助于降低致癌风险。角化过度症是慢性砷中毒患者生活和劳动的困扰，经5年观察其改善情况。33例角化过度症状改善者20例，无变化者11例，症状加重者2例。角化过度有改善的趋势，且从无机砷暴露减少的年份开始就与重症患者一样显著。此外，这些患者组还调查了第5年皮肤表现的改善情况。检查过的患者逐渐减少。在第五年的调查中，角化过度的改善只有两人。尽管在山西进行了类似的研究，但重症患者承认角化过度症有所改善。轻病者对角化过度缺乏改善意愿，继续无机砷暴露。人们认为，饮用水和食物对角化过度的有效改善是必要的，而饮用水和食物有望减少进一步的无机砷接触。少

The examination of the extermination of the chronic arsenic poisoning was tried in the Inner Mongolia and Shanxi in China. Whether the hyperkeratosis was able to be improved to the patiant with the chronic arsenic poisoning especially in this research because of the abatement of the amount of the exposure of the arsenic was verified. The respondent to a survey is a villager who resides in the Inner Mongolia, Baotou City, and the population of this village is 430 families, and 2080 people. The villager makes a living by agriculture and stock raising, and family's life and dining habit are almost the same. 96 people were elected from the villager, and the doctors of dermatology examined it. The measurement of the arsenic in urine and 8- OHdG concentrations was executed. The standard value 0.05ppm or less of the arsenic of the drinking water of China was supplied to the reduction of the inorganic arsenic exposure to the patients. This well water (water supply of tube type) was used the dr … More inking water and to cook. The patient's arsenic exposure has decreased to about 1/2 by improving the well water. It is thought that the improvement is admitted as for the oxidative DNA damage because of the reduction of the inorganic arsenic exposure, and this result contributes to the decrease in a carcinogenic risk. The improvement of the hyperkeratosis that was the trouble of life and the labor of the patiant with the chronic arsenic poisoning was observed for five years. The improvement of the hyperkeratosis is 20 of 33, there was no change 11 people, two people are the symptom exacerbations. The hyperkeratosis was the tendency to the improvement, and was remarkable like the serious illness person from the reduction of the inorganic arsenic exposure year first. In addition, these patient groups investigated the improve of the skin manifestation in year fifth. The number of patients who had inspected it was gradually 25 decreasing people. In the investigation of year fifth, the improvements of the hyperkeratosis were only two people. The serious illness person admitted the improvement of the hyperkeratosis though a similar research was executed in Shanxi. The slight illness person lacked the improvement desire of the hyperkeratosis, and the inorganic arsenic exposure was continued. It was thought that the drinking water and food from which the reduction of a further inorganic arsenic exposure was expected were necessary for an effective improvement of the hyperkeratosis. Less