Research on the improvement of the chronic arsenic poisoning in China

我国慢性砷中毒改善研究

• 批准号: 15406030
• 负责人: YAMAUCHI Hiroshi
• 金额: $ 8.13万
• 依托单位: St.Marianna University School of medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15406030/
• 关键词: Chronic arsenic poisoning; Hyperkeratosis; Carcinogenic; Oxidative DNA damage; Arsenic contamination; Well water; Extermination; China

The examination of the extermination of the chronic arsenic poisoning was tried in the Inner Mongolia and Shanxi in China. Whether the hyperkeratosis was able to be improved to the patiant with the chronic arsenic poisoning especially in this research because of the abatement of the amount of the exposure of the arsenic was verified. The respondent to a survey is a villager who resides in the Inner Mongolia, Baotou City, and the population of this village is 430 families, and 2080 people. The villager makes a living by agriculture and stock raising, and family's life and dining habit are almost the same. 96 people were elected from the villager, and the doctors of dermatology examined it. The measurement of the arsenic in urine and 8- OHdG concentrations was executed. The standard value 0.05ppm or less of the arsenic of the drinking water of China was supplied to the reduction of the inorganic arsenic exposure to the patients. This well water (water supply of tube type) was used the dr … More inking water and to cook. The patient's arsenic exposure has decreased to about 1/2 by improving the well water. It is thought that the improvement is admitted as for the oxidative DNA damage because of the reduction of the inorganic arsenic exposure, and this result contributes to the decrease in a carcinogenic risk. The improvement of the hyperkeratosis that was the trouble of life and the labor of the patiant with the chronic arsenic poisoning was observed for five years. The improvement of the hyperkeratosis is 20 of 33, there was no change 11 people, two people are the symptom exacerbations. The hyperkeratosis was the tendency to the improvement, and was remarkable like the serious illness person from the reduction of the inorganic arsenic exposure year first. In addition, these patient groups investigated the improve of the skin manifestation in year fifth. The number of patients who had inspected it was gradually 25 decreasing people. In the investigation of year fifth, the improvements of the hyperkeratosis were only two people. The serious illness person admitted the improvement of the hyperkeratosis though a similar research was executed in Shanxi. The slight illness person lacked the improvement desire of the hyperkeratosis, and the inorganic arsenic exposure was continued. It was thought that the drinking water and food from which the reduction of a further inorganic arsenic exposure was expected were necessary for an effective improvement of the hyperkeratosis. Less

在内蒙古和山西进行了慢性砷中毒根治试验。证实了慢性砷中毒患者的角化过度是否能因砷暴露量的减少而得到改善，特别是本研究。调查对象是内蒙古包头市的一位村民，全村人口430户，2080人。村民以农牧业为生，一家人的生活和饮食习惯几乎相同。从村民中选出96人，由皮肤科医生进行检查，并进行尿砷和8- OHdG浓度的测定。提出了我国饮用水砷标准值为0.05ppm以下，以减少患者无机砷暴露。这种井水（管道式供水）被用于 ...更多信息 水和烹饪。通过改善井水，患者的砷暴露量已降至约1/2。据认为，由于无机砷暴露的减少，氧化性DNA损伤的改善是公认的，并且该结果有助于降低致癌风险。对慢性砷中毒患者的生活和劳动障碍--角化过度进行了五年的观察。33例角化过度者中有20例好转，11例无变化，2例症状加重。从无机砷暴露量减少的第一年开始，角化过度有改善的趋势，且与重病者一样显著。此外，这些患者组在第5年调查了皮肤表现的改善。检查过它的病人人数逐渐减少25人。在第五年的调查中，角化过度的改善只有两个人。虽然在山西进行了类似的研究，但重病患者承认角化过度得到改善。轻症者缺乏角化过度的改善愿望，继续无机砷暴露。据认为，饮用水和食物，从进一步减少无机砷暴露，预计是必要的，有效改善角化过度。少

项目成果

Dose-response relationship between arsenic exposure and arsenic relating chronic Symptoms observed in residents exposing to arsenic via drinking water

砷暴露与砷相关慢性症状的剂量-反应关系 通过饮用水接触砷的居民观察到的症状

• 发表时间: 2004
• 期刊: Toxicology and Applied Pharmacology
• 影响因子: 3.8
• 作者: Tajima A;Hamaguchi K;Terao H;Oribe A;Perrotta VM;Baez CA;Arias JR;Yoshimatsu H;Sakata T;Horai S.;Takahiko Yoshida et al.
• 通讯作者: Takahiko Yoshida et al.

分子予防環境医学

分子预防环境医学

• 发表时间: 2004
• 作者: Shiomi;N.;高野裕久
• 通讯作者: 高野裕久

救急医学

急诊医学

• 发表时间: 2014
• 作者: 浅沼博司;伊原まどか;北風政史
• 通讯作者: 北風政史

Chronic health effects in people to arsenic via the drinking water : dose- exposed response relationships in review.

通过饮用水对砷对人的慢性健康影响：回顾剂量暴露反应关系。

• 发表时间: 2004
• 期刊: Toxicol Appl Pharmacol 198
• 作者: Tajima A;et al.;Yoshida et al.
• 通讯作者: Yoshida et al.

A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits

• DOI: 10.1016/s0891-5849(03)00269-7
• 发表时间: 2003-07-01
• 期刊: FREE RADICAL BIOLOGY AND MEDICINE
• 影响因子: 7.4
• 作者: Pi, JB;Horiguchi, S;Kumagai, Y
• 通讯作者: Kumagai, Y