Study on epidemiology of the chronic arsenic poisoning in China

目前全球范围内井水的无机砷污染已造成大规模的慢性砷中毒。我国约有1300万人，印度约有1000万人，中国估计约有200万人，慢性砷中毒的症状出现的早晚约占高浓度无机砷暴露者总数的20%。本研究的调查区域为内蒙古和山西省。本研究的产品即为上述结果。慢性砷中毒的原因是井水中含有的砷酸盐。一天从井水中摄入砷的平均推测量表明，达到约1 mg和约3 mg的机会是经常存在的。慢性砷中毒患者肝脏对砷酸盐进行了解毒（两阶段甲基化）。慢性微量无机砷中毒的皮肤表现 关于我们 老年暴露（井水砷浓度为0.05-1 ppm）有砷中毒的趋势，依次为领部物质漂白、色素沉着、背部腹部手足部砷角化病。高浓度无机砷暴露所致慢性砷中毒的皮肤表现（1-3 ppm）证实了1例与色素漂白和色素沉着砷角化病同时出现或同时存在的病例。慢性砷中毒男性皮肤表现较女性更为严重。皮肤表现存在性别差异，无机砷暴露时间少于20年，未见致癌性。由于无机砷暴露，尿中DNA损伤物质（尿-8-羟基-2-鸟苷）的测定对尿中致癌性的风险评价是有效的。通过对慢性砷中毒患者的排泄试验，发现饮用0.05ppm以下的饮用水能使砷迅速排出体外，阐明了预防和改善慢性砷中毒的可能性。具体地说，砷角化病澄清了使用0.05ppm或更少的饮用水的改善。减

Large-scale with the chronic arsenic poisoning is generated by the inorganic arsenic contamination of the well water now globally. They are about 13,000,000 people, India is 10,000,000 people, and it is guessed that China is 2,000,000 people, and the symptom of the chronic arsenic poisoning appears about 20% sooner or later the total of high concentration those who expose inorganic arsenic. The region of this research for the investigation in Inner Mongolia and Shanxi Province. The products in this research is the under mentioned results. The cause of the chronic arsenic poisoning is an arsenate, which the well water contains. The amount of the arsenic intake of average presumption from the well water during a day clarified that the chance to reach about 1mg and about 3mg existed frequently. The chronic arsenic poisoning patient had the detoxification (methylate of two stages) for an arsenate in the liver. The skin manifestation of the chronic arsenic poisoning by a slight inorganic ar … More senic exposure (As concentrations is 0.05-1 ppm in well water) had the tendency admitted in order of the arsenical keratosis of the collaring matter bleaching, the pigmentation, and the hand and the foot of the abdomen in the back.The skin manifestation of the chronic arsenic poisoning from a high concentration inorganic arsenic exposure (for 1-3 ppm) confirmed a case, which appeared or was preceding at the same time as the coloring matter bleaching and the pigmentation arsenical keratosis existed. Man's skin manifestation in the chronic arsenic poisoning was a serious illness compared with the woman. The difference of the sex difference existed in the skin manifestation.The inorganic arsenic exposure was observed and carcinogenecity was not observed for less than 20 years. The measurement of the DNA damage material (urinary-8-hydroxyl-2-guanosine) was effective for the risk evaluation of carcinogenecity in urine because of the inorganic as exposure. The chronic arsenic poisoning patient was excreted and the arsenic was excreted from inside the body rapidly by using the drinking water of 0.05ppm or less. Possible prevention and the improvement of the chronic arsenic poisoning were clarified. Concretely, the arsenic-keratosis clarified the improvement by using the drinking water of 0.05ppm or less. Less