Research on the improvement and prevention countermeasure of the chronic arsenic poisoning in China

我国慢性砷中毒的改善及预防对策研究

• 批准号: 13576018
• 负责人: YAMAUCHI Hiroshi
• 金额: $ 6.53万
• 依托单位: St. Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13576018/
• 关键词: Chronic arsenic poisoning; China; Epidemiology; methylation; well-water; carcinogenesis; DNA damage; 8-OHdG; 予防

The inorganic arsenic, which causes chronic arsenic poisoning, is contained in the mineral, which exists in the underground rock board of the mountain range dotted with the Great Wall of China. As for these mountain ranges, ancient times were volcano. The ground water, which passed through the rock board, which contained arsenic, reached the plain of the Inner Mongolia and Shanx, and arsenic contaminated the subterranean water of the basin of the low land. The chronic arsenic poisoning breaks out in the people who dug it and who were used for life water in those areas the well. There is good relationship between the sideration of the Chinese chronic arsenic poisoning and the posterior release policy of the Great Cultural Revolution. In other words, the start of the inorganic arsenic exposure of the high concentration is 1978-1980 years.It is serious keratosis and cancer of skin to cause a trouble with the chronic arsenic poisoning. We continued research about the elucidation of the dev … More elopmental mechanism of the chronic arsenic poisoning in China and illness improvement and the prevention countermeasure. The cause of the chronic arsenic poisoning explained arsenate and a method such as relations between the amount of arsenic exposure and the sideration time and sick improvement and a prevention countermeasure in the research. The main symptom of the chronic arsenic poisoning is dermatopathy. Keratosis breaks out in the palm and the planta pedis at 5-6 years after that as to the pigmentation and the dipigmentation. It depends on the intake of the arsenic. Pigmentation, dipigmentation and keratosis are coincidental within 1 year when an intake (3-5 mg) on the 1st is large. As for the symptoms of chronic arsenic poisoning, it confirmed that adults were worse than children. Sex difference exists in the symptoms of chronic arsenic poisoning, and a man compares it to the woman, and becomes clearly seriously ill. 100 patients were made the target, and improvement was confirmed clearly with a half year and the thing after 1 year as for the improvement plan of keratosis in this research when an arsenic exposure on the 1st was restricted to less than 0.1m g. The deoxyribonucleic acid which had an injury given by arsenic was recovered to the normal territory in the same way, too. It thinks about the result of this research with the scientific basis which can be applied to the guidelines on the improvement plan of the posterior chronic arsenic poisoning now. Less

导致慢性砷中毒的无机砷存在于矿物中，这种矿物存在于中国长城点缀的山脉的地下岩石板中。至于这些山脉，在古代是火山。地下水，其中通过岩石板，其中含有砷，到达内蒙古和山西的平原，砷污染了低地盆地的地下水。慢性砷中毒发生在那些挖井的人和那些在那些地区用井作为生活用水的人身上。对中国慢性砷中毒的认识与文革后的释放政策有着密切的关系。也就是说，高浓度无机砷暴露开始于1978-1980年，引起慢性砷中毒的是严重的角化病和皮肤癌。我们继续研究关于发展的说明， ...更多信息 我国慢性砷中毒发病机制、病情改善及防治对策慢性砷中毒的病因、砷暴露量与考虑时间、病情改善的关系等方法及预防对策的研究。慢性砷中毒的主要症状是皮肤病。在色素沉着和色素脱失后5-6年，手掌和足底发生角化病。这取决于砷的摄入量。当第一天摄入量（3-5 mg）较大时，色素沉着、色素脱失和角化病在1年内是巧合的。至于慢性砷中毒的症状，证实成人比儿童更严重。慢性砷中毒的症状存在性别差异，男性与女性相比，病情明显加重。本研究以100例患者为研究对象，在砷暴露量控制在0.1mg以下的情况下，角化病的改善方案在半年和1年后均得到了明显的改善。砷损伤的脱氧核糖核酸也以同样的方式恢复到正常范围。认为本研究结果可作为指导目前慢性砷中毒后改善方案的科学依据。少

项目成果

網中雅仁, 山内 博, 木村慎吾, 千葉啓子, 吉田勝美: "日本人健常者の尿中ポルフィリン濃度に関する研究"臨床環境医学. 11・1. 29-35 (2002)

Masahito Aminaka、Hiroshi Yamauchi、Shingo Kimura、Keiko Chiba、Katsumi Yoshida：“日本健康受试者尿中卟啉浓度的研究”11・1（2002）。

A. Shram, S. Hirano, H. Yamauchi: "Extraction and speciation of arsenic in hair using HPLC-ICPMS"Analytical Science. 17. 1729-1732 (2001)

A. Shram、S. Hirano、H. Yamauchi：“使用 HPLC-ICPMS 提取头发中的砷并进行形态分析”分析科学。

P.Pi, H. Yamauchi, Y.Kumagai, et. al.: "Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water"Environmental Health. 110-4. 331-336 (2002)

P.Pi、H. Yamauchi、Y.Kumagai 等。

P.Pi, H.Yamauchi, Y.Kumagai, et al.: "Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water"Environmental Health. 110. 331-336 (2002)

P.Pi、H.Yamauchi、Y.Kumagai 等人：“中国居民长期接触饮用水中的砷而引起氧化应激的证据”环境健康。

山内博, 山村行夫: "砒素中毒"中毒診療実践ガイド. 160-163 (2001)

Hiroshi Yamauchi、Yukio Yamamura：“砷中毒”中毒治疗实用指南 160-163 (2001)。