Effects of polymorphism and lifestyle for the fractions of serum LDL cholesterol

我们在日本和蒙古进行了小而密LDL和氧化LDL的流行病学研究，这两种LDL被认为是冠心病的危险因素。1）日本和蒙古的国际比较研究对30-60岁的283名日本人和258名蒙古人进行了流行病学调查研究。日本人和258名蒙古族低密度脂蛋白小而密者的BMI、血清甘油三酯、胰岛素、瘦素和氧化型低密度脂蛋白均高于中、高密度脂蛋白者，而血清高密度脂蛋白则低于中、高密度脂蛋白者。蒙古族生长性脂肪较多者小而密LDL的患病率低于日本人。这些结果表明，小而密的LDL与未知因素有关，除了肥胖、血清甘油三酯、VLDL。2）通过自我学习和自我决定对内脏肥胖的干预研究2000年的参与者人数为23人（51%），2001年的参与者人数为30人（73%）。通过干预措施，2000年和2001年的低密度脂蛋白含量分别改善了25和33。它与生活活动程度的增加、血清甘油三酯和胰岛素抵抗的降低、血清高密度脂蛋白胆固醇的升高密切相关。血清LDL浓度的降低与干预后血浆氧化LDL无关。血浆氧化型低密度脂蛋白（LDL）浓度小、密度高者高于LDL大者。与LDL体积较大的人相比，LDL体积小、密度大的人在LDL组分密度中氧化LDL的浓度较高。很明显，小而致密的LDL含有更高的氧化LDL，其被apoB的侧链修饰。

We conducted epidemiological studies of small, dense LDL and oxidized LDL, which were suggested risk factors for coronary heart diseases, in Japanese and Mongolian.1) The international comparative research for Japanese and MongolianA study of epidemiological investigation was carried out for 283 of Japanese and 258 of Mongolian aged 30-60 years old. Japanese and 258 of Mongolian with small, dense LDL had higher BMI, higher of serum triglyceride, insulin, leptin and oxidized LDL, and lower of serum HDL blood, compared to persons with intermediate or large LDL size. The prevalence of small, dense LDL in Mongolian who had many growing fat was lower than Japanese. These results suggest that small, dense LDL is related with unknown factors, except for obesity, serum triglyceride, VLDL.2) Interventional study by self-learning and self-determination for visceral obesityNumber of participants decreased with their body weight was 23 (51 %) in 2000 and 30 (73 %) in 2001. An improvement of LDL size by the intervention was 25 in 2000 and 33 in 2001. It related to increase in a degree of life activities strongly, and a decrease of serum triglyceride and insulin resistance, increase in serum HDL cholesterol. A decrease in serum LDL concentration was not associated plasma oxidized LDL by the intervention. Plasma oxidized LDL was higher concentration in persons with small, dense LDL than persons with bigger size of LDL. Persons with small, dense LDL had higher concentration of oxidized LDL in dense gravity of LDL fraction, compared with persons with bigger size of LDL. It became clear that small, dense LDL contained higher oxidized LDL modified with the side chain of apoB.