The relationship between genetic polymorphism and lifestyle for visceral obesity

葡萄糖耐量异常、高血压和血脂异常的聚集被称为代谢综合征。亚洲人肥胖的发生率低于高加索人，但有代谢综合征的趋势。内脏肥胖已被认为是代谢综合征最重要的决定因素。肥胖症在亚洲国家迅速增加，并已成为亚洲普遍的健康问题。β_3肾上腺素能受体（β_3AR）基因Trp 64 Arg突变在日本人中较为常见。但β_3AR基因Trp 64 Arg突变者是否易发生肥胖，且在限制饮食和运动的情况下仍难以减肥，目前尚不清楚。我们调查了β_3AR基因Trp 64 Arg突变的日本女性的体重和代谢因素对行为干预的反应。本研究结果提示β_3 AR基因Trp 64 Arg突变与肥胖症患者减肥困难有关， ...更多信息 成年人肥胖的患病率，如BMI等于或大于30.0，在大多数西欧国家为10-25%，在美洲为20-25%。BMI组的分级增加与代谢综合征的患病率呈正相关。与“正常”日本人相比，“超重”日本人的代谢综合征患病率显著较高，而其他两个种族的“超重”人群则没有。目前的研究表明，代谢综合征受BMI的影响，并可能受到饮食中代谢成分的影响，这反过来又可能以种族特异性的方式对代谢综合征产生一定的影响。累积的证据表明，高甘油三酯血症（HTG）与心血管疾病的发病率增加独立相关。日本人和韩国人的甘油三酯值高于蒙古人，尽管日本人和韩国人的BMI值较低。日本人和朝鲜人吃鱼的频率更高，n-3 PUFA值显著高于蒙古人。多元回归分析显示，日本人和蒙古人的甘油三酯水平与18：1/18：0比值的增加有很大的相关性，蒙古人的n-3 PUFA仍有显著性。HTG与日本人、韩国人和蒙古人血浆中18：1/18：0比例增加或n-3 PUFA减少具有种族特异性相关性。少

A clustering of abnormal glucose tolerance, hypertension and dyslipidemia has been, labeled as metabolic syndrome. Asians have a lower frequently of obesity than do Caucasians, but have an increasing tendency toward metabolic syndrome. Visceral, obesity has been proposed as the most important determinant of metabolic syndrome. Obesity is increasing rapidly in Asian countries and has become, a common health problem in Asia. Trp64Arg mutation in the β_3-adrenergic receptor (β_3AR) gene is relatively common in Japanese people. However, it has not been clear whether persons with Trp64Arg mutation, in the β_3AR gene tend to have obesity and difficulty in losing weight even with a restricted diet and exercise. We investigated the response of body weight and metabolic factors to behavioral intervention in Japanese women with Trp64Arg mutation in the β_3AR gene. Results of the present study suggest that the Trp64Arg mutation of the β_3AR gene is associated with difficulty in losing weight thro … More ugh the behavioral intervention, although it is not related to obesity-related phenotypes and resting energy expenditure before the intervention.The prevalence of adult obesity, as BMI equal to or greater than 30.0, ranges from 10-25% in most Western Europe countries and 20-25% in the Americas. Graded increases in BMI groups were positively associated with the prevalence of metabolic syndrome. The "Overweight" Japanese had a significantly higher prevalence of metabolic syndrome, compared with "Normal" Japanese, in contrast to the "Overweight" in the other two ethnic groups, who did not. The present investigation suggests that metabolic syndrome is affected by BMI and may be affected by the metabolic component of the diet, which in turn may have some impact on metabolic syndrome in an ethnic specific manner. Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower BMI values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkable higher-values for n-3 PUFA than did the Mongolians. Multiple regression analysis showed that, triglyceride levels had a great magnitude of correlation with increases in the 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFA remained significant for the Mongolians. HTG is ethnic specifically associated with an increase in the 18:1/18:0 ratio or a decrease in n-3 PUFA in plasma for the Japanese, Koreans and Mongolians. Less