Interaction between genetic and environmental factors in metabolic syndrome

胰岛素抵抗、高血压和血脂异常的群集被标记为代谢综合征。亚洲人患肥胖症的频率比白种人低，但患代谢综合征的趋势却在增加。大多数关于代谢综合征的数据都是基于西方国家的研究，只有有限的来自亚洲人群的信息。为了研究β -肾上腺素能受体（β - 3ar）基因Trp64Arg多态性与解偶联蛋白1 （UCP1）基因（-3826）A〓>G多态性与日本人减肥的相关性，在2000 - 2005年进行了为期3个月的社区教育干预试验，其中男性72人（53.5±11.6岁），女性228人（55.8±9.1岁）。参与者中有28%的人超重（23.0-24.9 BMI）， 48%的人肥胖（= 25 BMD）。每位受试者完成生活方式改变方案，体重减轻1.33±0.11 kg，能量平衡385±24.05 kcal。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析了beta3AR和UCP1的多态性。采用通用线性模型（General Linear Model, GLM-1）检测体重变化与两种基因多态性之间的关系。在控制了潜在的混杂变量（p=0.007）后，携带β 3ar突变的女性体重显著降低，而男性没有（p=0.007）。UCP1多态性对体重变化的影响在女性和男性中均不显著。β 3ar和UCP1多态性对体重变化的协同效应未发现加性效应（p=0.167）。beta3AR和UCP1基因多态性的协同效应可能是日本超重肥胖人群体重变化的一个微弱因素。我们还对工作场所18-60岁的个体进行了横断面研究。根据国际糖尿病联合会（IDF）的定义，我们检查并分析了1564名日本、中国和蒙古人的代谢综合征健康数据。以亚洲版腰围计算的内脏肥胖患病率，日本人分别为10%和12%，中国人分别为39%和24%，蒙古人分别为51%和54%。代谢综合征患病率，日本人分别为7%和7%，中国人分别为24%和9%，蒙古人分别为22%和24%，日本人发生内脏肥胖的频率低于中国人和蒙古人，但与肥胖相关的代谢紊乱有增加的趋势。随着社会经济的发展，亚洲劳动者的肥胖和代谢综合征呈上升趋势，但与肥胖相关的代谢紊乱在种族间存在显著差异。少

A clustering of insulin resistance, hypertension and dyslipidemia has been labeled as metabolic syndrome. Asians have a lower frequency of obesity than do Caucasians, but have an increasing tendency toward metabolic syndrome. Most data on metabolic syndrome am based on studies from Western countries with only limited information derived from Asian populations.To investigate the independent and combined effects of the Trp64Arg polymorphism of the beta3-adrenergic receptor (beta3AR) gene and the (-3826) A〓>G polymorphism of the uncoupling protein 1 (UCP1) gene are associated with weight-loss of Japanese. 300 subjects (72 men of 53.5±11.6 years and 228 women of 55.8±9.1 years) participated in a community-setting educational interventional trials for three months from 2000 to 2005. Participants were 28% overweight (23.0-24.9 BMI) and 48% obese (〓25 BMD. Each subject was completed the life-style modification program, and reduced 1.33±0.11 kg of weight, 385±24.05 kcal of energy balance. The … More beta3AR and UCP1 polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). General Linear Model (GLM-1) was fit to detect associations between body weight changes and the two gene polymorphisms. The body weight significantly reduced in women with beta3AR mutation but not in men, after controlling for potential confounding variables (p=0.007). The effect of UCP1 polymorphism on body weight change was not significant in both women and men. The synergistic effects of polymorphisms both beta3AR and UCP1 on body weight changes were not found to have additive effects (p=0.167). The synergistic effect of the beta3AR and the UCP1 gene polymorphism may be a weak contributing to body weight changes in Japanese with overweight and obese.We also conducted a cross-sectional study of individuals aged 18-60 yr in workplace settings We examined and analyzed the health data of 1,564 Japanese, Chinese and Mongolians for metabolic syndrome based on the International Diabetes Federation (IDF) definition. The prevalence of visceral obesity using the Asian edition of waist circumference was 10% and 12% for Japanese, 39% and 24% for Chinese, and 51% and 54% for Mongolians, respectively The prevalence of metabolic syndrome was 7% and 7% for Japanese, 24% and 9% for Chinese, and 22% and 24% for Mongolians respectively Japanese has a lower frequency of visceral obesity than do Chinese and Mongolians, but have an increasing tendency toward obesity-related metabolic disorders. Obesity and metabolic syndrome are increasing in Asian workers with their social-economical development, but obesity-related metabolic disorders are remarkably different relative to ethnicity. Less