Studies on the effects of heat shock proteins of the HSP110 family on the aggregation of poly-glutamine

HSP110家族热休克蛋白对聚谷氨酰胺聚集影响的研究

• 批准号: 12670603
• 负责人: ITOH Katsuhiko
• 金额: $ 2.18万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670603/
• 关键词: APG-1; APG-2; HSP110; HSP70; polyglutamine; aggregation; apotosis; ポリグルタミン; 凝集体; HSP40

1. We have studied the effects of HSP110, APG-1 or APG-2, which are belonging to the HSP110 family, on the aggregation of poly-glutamine in vitro. Although HSP70 inhibited the aggregation of poly-glutamine, these molecules did not inhibited.2. We have studied the effects of HSP110, APG-1 or APG-2 on the Poly-glutamine induced apoptosis in vitro. Although HSP70 inhibited the apoptosis, these molecules did not inhibited.3. We have observed that HSP70 whith lacks its ATPase domain showed the anti-aggregation effect on polu-glutamine but not the anti-apoptotic effect.

1.本文研究了热休克蛋白110（HSP 110）家族成员之一的热休克蛋白110（HSP 110）及其衍生物APG-1、APG-2对聚谷氨酰胺（poly-glutamine）体外聚集的影响。HSP 70抑制聚谷氨酰胺的聚集，但不抑制这些分子的聚集.本实验研究了HSP 110、APG-1、APG-2对多聚谷氨酰胺（Poly-glutamine）诱导的体外细胞凋亡的影响。HSP 70抑制细胞凋亡，但这些分子并不抑制细胞凋亡.我们观察到缺乏ATP酶结构域的HSP 70对多聚谷氨酰胺有抗聚集作用，但没有抗凋亡作用。

项目成果

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