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Studies on the effects of heat shock proteins of the HSP110 family on the aggregation of poly-glutamine

Studies on the effects of heat shock proteins of the HSP110 family on the aggregation of poly-glutamine
HSP110家族热休克蛋白对聚谷氨酰胺聚集影响的研究
批准号:
12670603
负责人:
ITOH Katsuhiko
金额:
$2.18万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2000
资助国家:
日本
项目状态:
已结题
起止时间:
2000 至 2001

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中文摘要
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英文摘要
1. We have studied the effects of HSP110, APG-1 or APG-2, which are belonging to the HSP110 family, on the aggregation of poly-glutamine in vitro. Although HSP70 inhibited the aggregation of poly-glutamine, these molecules did not inhibited.2. We have studied the effects of HSP110, APG-1 or APG-2 on the Poly-glutamine induced apoptosis in vitro. Although HSP70 inhibited the apoptosis, these molecules did not inhibited.3. We have observed that HSP70 whith lacks its ATPase domain showed the anti-aggregation effect on polu-glutamine but not the anti-apoptotic effect.
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Ohnishi et al.: "High expression of transganes mediated by hybrid retrovival vectors in hepatocytes : coinparison of promoters from murine vetroviruse in vitro and invivo"Gene Therapy. (in press). (2002)
Ohnishi 等人:“杂合逆转录病毒载体在肝细胞中介导的转基因的高表达:小鼠静脉病毒启动子在体外和体内的比较”基因治疗。
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Tatsumi K et al.: "Induction of tryptophan 2,3-Dioxygenase in the mouse endometrium during implantation"Biochem Biophys Res Commun. 274. 166-170 (2000)
Tatsumi K 等人:“植入期间小鼠子宫内膜中色氨酸 2,3-双加氧酶的诱导”Biochem Biophys Res Commun。
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Hirose Y, Kiyoi H, Itoh K, KatoK, Saito H and Naoe T.: "B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells"Immunology. 104. 41
Hirose Y、Kiyoi H、Itoh K、KatoK、Saito H 和 Naoe T.:“从脐带血 CD34 细胞分化而来的 B 细胞前体比源自粒细胞集落刺激因子动员的外周血 CD34 细胞的 B 细胞前体更不成熟”。
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通讯作者:
Hirose Y et al.: "B-cell precursors differentiated from cord blood CD34^+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34^+ cells"Immunology. 104. 410-417 (2001)
Hirose Y 等人:“从脐带血 CD34+ 细胞分化而来的 B 细胞前体比源自粒细胞集落刺激因子动员的外周血 CD34+ 细胞的 B 细胞前体更不成熟”。
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13
    Direct reprogramming of fibroblasts to hemetopoietic stem cells
    • 批准号:
      23659202
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2011
    • 负责人:
      ITOH Katsuhiko
    • 依托单位:
    Studies on the trans-differentiation of hematopoietic stem cells and the application for the gene therapy
    • 批准号:
      14570975
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2002
    • 负责人:
      ITOH Katsuhiko
    • 依托单位:
    Development of novel packaging cells for refrovirus vectors based on stromal cells
    • 批准号:
      11670993
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      1999
    • 负责人:
      ITOH Katsuhiko
    • 依托单位:
    Development of a novel retrovirus vector system for hematopoietic Stem cells
    • 批准号:
      09671106
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      1997
    • 负责人:
      ITOH Katsuhiko
    • 依托单位:
    海外基金