Alterations of the functions of imidazoline-1 and alpha 2 adrenergic receptors in the medulla oblongata in the development of heart failure

延髓中咪唑啉 1 和 α 2 肾上腺素能受体在心力衰竭发展过程中功能的改变

• 批准号: 12670702
• 负责人: SATO Naoki
• 金额: $ 2.05万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670702/
• 关键词: Heart Failure; Imidazoline receptor; alpha2 adrenergic receptor; α_2アドレナリン受容体; 交換神経系; 心機能; 圧受容体反射

Background/Goal : Sympathetic activation is a hallmark of heart failure (HF). Clinical investigation have demonstrated usefulness of beta-blocker treatment for HF. However, it has not been well established whether nor not central symapthoinhibition could be favorable for the progression of HF, although it is known that activation of imidazoline receptors in central nervous system suppresses sympathetic outflow and decreases plasma norepinephrine levels. Therefore, our goal was to examine the effects of chronic administration of an imidazoline receptor agonist, rilmenidine (RIL), on HF in conscious beagles.Methods : Twelve beagles were chronically instrumented for intra-atrial infusions of saline or RIL (0.5mg/kg/day over 5 weeks) and rapid pacing at 250 bpm. Echocardiography was performed before and after HF for measurements of left ventricular ejection fraction (LVEF), % fractional shortening (%FS), and LF end-diastolic dimension (EDD).Results : Heart rate, %FS, LVEF, and EDD between control (C, n=6) and RIL(n=6) groups were not different before HF (C:126±31,38.1±9.0,68.1±11.0,35.6±3.5, RIL:121±17bpm,39.7±6.6%,70.8±7.9%,33.4±4.1mm, respectively). LV functions (%FS, LVEF, and EDD) in RIL group was significantly (p<0.05) better than C (15.3±6.9 vs 7.7±2.4%,32.5±12.5 vs 17.2±5.2%,4.5±5.0 vs 48.0±2.0 mm, respectively).Conclusion : Central sympathoinhibition tolerated the development of HF, suggesting chronic suppression of symapthetiv outflow might be useful for the treatment of HF.

背景/目标：同情激活是心力衰竭（HF）的标志。临床研究表明，β受体阻滞剂治疗对HF的有用性。但是，尽管众所周知，中枢神经系统中咪唑啉受体的激活抑制交感输出流动并降低血浆去甲肾上腺素水平，但尚未确定中枢对抑制是否也有利于HF的进展。 Therefore, our goal was to examine the effects of chronic administration of an imidazoline receptor agonist, rilmenidine (RIL), on HF in conscious beagles.Methods: Twelve beagles were chronically instrumented for intra-atric infusions of saline or RIL (0.5mg/kg/day over 5 weeks) and rapid pacing at 250 bpm.在HF之前和之后进行超声心动图，以测量左心室发射分数（LVEF），％缩短％缩短（％FS）和LF末端舒张尺寸（EDD）。消除：心率，％FS，LVEF，LVEF和EDD在对照组之间（C，N = 6）和RIL（C，N = 6）和RIL（c，n = 6）和RIL（N = 6）是HF（N = 6）HF （C：126±31,38.1±9.0,68.1±11.0,35.6±3.5，RIL：121±17bpm，39.7±6.6％，70.8±7.9％，33.4±4.1mm）。 RIL组中的LV功能（％FS，LVEF和EDD）明显优于C（15.3±6.9 vs 7.7±2.4％，32.5±12.5，32.5±12.5 vs 17.2±5.2％，4.5±5.0，4.5±5.0 vs 48.0±2.0 mm，分别提出了intermention internal intermention intermention interminition interminition internistion intrencition intrencities。抑制对称出口可能对HF的治疗有用。

项目成果

Effects of central sympathoinhibition via imidazoline receptor activation on the progression of heart failure in conscious beagles

通过咪唑啉受体激活抑制中枢交感神经对清醒比格犬心力衰竭进展的影响

• 发表时间: 2003
• 期刊: Circ J 67
• 作者: Tokuyama K;Sato N;et al.
• 通讯作者: et al.

「研究成果報告書概要(欧文)」より

摘自《研究结果报告摘要（欧洲）》

• 发表时间: 2006
• 期刊: Seibutsu Butsuri 46(1)
• 作者: Yasushi Shigeri;Keiko Shimamoto
• 通讯作者: Keiko Shimamoto