权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Clinical severity of human calicivirus gastroenteritis in children

儿童人杯状病毒胃肠炎的临床严重程度

基本信息

批准号：
12670766
负责人：
NAKATA Shuji
金额：
$ 2.11万
依托单位：
Sapporo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670766/
关键词：
Family Caliciviridae Norwalk virus Sapporo virus RT-PCR Nested PCR Clinical severity Gastroenteritis outbreaks Sporadic gastroenteritis

项目摘要

Caliciviruses in animals and in humans are now classified in four Genera by ICTV in 1999. In humans, the Genus "Norwalk-like viruses" represented by Norwalk virus (NV) and the Genus "Sapporo-like viruses" represented by Sapporo virus (SV) are approved. To clarify the clinical significance and etiologic impact of NV and SV in viral gastroenteritis in Japanese children, two outbreaks each of NV gastroenteritis and SV gastroenteritis occurring in an infant home in Sapporo, Japan, as well as 95 hospitalized children with acute gastroenteritis were retrospectively evaluated using a 0 to 20 point clinical severity scoring system. The mean severity scores for NV and SV gastroenteritis outbreaks were 7.9 and 5.2, respectively, as compared to 8.4 for rotavirus A (RV-A) gastroenteritis that occurred in the same infant home. Among 95 hospitalized children with acute gastroenteritis, RV-A was detected in 47% followed by NV in 18%. SV was not found. The severity score of 13.2 in RV cases was the highest, followed by 12.3 in NV cases and ll.3 in unknown etiology cases, and they were judged as severe cases irrespective of the etiologic agents. In the extremely severe cases, in which the score was ≧14, a viral etiology was established in 78%; RV in 56% and NV in 22%. Our data indicate that NV can cause severe gastroenteritis and is an important etiologic agent in hospitalized cases while SV causes mild gastroenteritis in children in Japan.

1999年ICTV将动物和人类中的杯状病毒分为四个属。在人类中，批准了以诺瓦克病毒（NV）为代表的“诺瓦克样病毒”属和以札幌病毒（SV）为代表的“札幌样病毒”属。为了阐明NV和SV在日本儿童病毒性胃肠炎中的临床意义和病原学影响，使用0 - 20分临床严重程度评分系统回顾性评价了日本札幌婴儿家中发生的NV胃肠炎和SV胃肠炎各两次暴发以及95例急性胃肠炎住院儿童。NV和SV胃肠炎爆发的平均严重程度评分分别为7.9和5.2，而发生在同一婴儿家中的轮状病毒A（RV-A）胃肠炎为8.4。在95例急性胃肠炎住院患儿中，RV-A检出率为47%，其次为NV，检出率为18%。RV的严重程度评分最高，为13.2分，NV为12.3分，病因不明的病例为11.3分，无论病因如何，均被判定为严重病例。在非常严重的病例中，评分为14分，其中78%确定了病毒病因; RV为56%，NV为22%。我们的数据表明，在日本，NV可引起严重的胃肠炎，是住院病例的重要病原体，而SV可引起儿童轻度胃肠炎。