Analysis of expression mechanism of endostatin and angiostatin

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We reported tat endostatin expression correlated with tumor size and p53 expression, but not lymph node status and prognosis, and that high endostatin expression correlated with high microvessel density in the primary tumor. Endogenous endostatin which may be upregulated by p53 gene dices not represent antiangiogenic phenotype of the primary tumor.Endostatin inhibits iNOS activity, in thyroid anapiastic carcinoma, maxillary carcinoma, and lung carcinoma cell lines, 2. Inhibition of iNOS activity by endostatin may cause to antoangiogenesis.We speculate a pathway of antiangiogic function of endostatin fron these results. Endostatin inhibits iNOS activity, leading to decrease of NO production in NOS expressed tumor cells. Loss of NO production may cause to antiangiogenesis through inhibition of VEGF and increase of p53 accumulation.