Studies on migration of metal ions originated from cast post and antigen presenting ability of periodontal ligament cells.

铸桩源金属离子迁移及牙周膜细胞抗原呈递能力的研究。

• 批准号: 12671875
• 负责人: UOSHIMA Katsumi
• 金额: $ 2.18万
• 依托单位: NIIGATA UNIVERSITY (2002)Tokyo Medical and Dental University (2000-2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671875/
• 关键词: Dental Metal Allergy; Dental alloy; Dentin permeability; Allergen Removal; Metal abutment; 金属性支台装置

We have been seeing allergic patients for more than fourteen years in our metal allergy clinic. Currently, one of our major questions is whether we should remove metal cast post that contains allergens out of allergic patient's mouth, in case of the metal is not directly exposed to the oral cavity. Because there should be certain risks removing cast post out of the tooth. The purpose of this study was to investigate the distance of corroded ions from cast post migrating outward along the root dentinal tubules to seek the guideline for removal of cast post in case of metal allergy.First, we investigated the extracted teeth that had metal post inside and whose treatment histories were known using the highest resolution EPMA. However, there were no detectable metal ions when we investigated the cut surface of the teeth. Then we carried out several types of in vitro experiments simulating intra oral mouth conditions using orthodontically extracted teeth. As far as we found using most sensitive machine we have currently, there were only negligible copper migrated to root dentine from cast post in several hundred micrometer. We could not conclude that there was no possibility for corroded metal ions from cast posts exit the outer root surface. However, the removal of cast posts that are not exposed, out of allergic patients may have less priority than other treatments because it is less likely for the patients to be exposed to the allergen at high concentration.Further careful investigations will be needed.

在金属过敏诊所中，我们已经看到过敏患者已有14多年了。目前，我们的主要问题之一是，如果金属不直接暴露于口腔，我们是否应该删除从过敏患者口中含有过敏原的金属铸件柱。因为应该有一定的风险从牙齿中清除。这项研究的目的是研究腐蚀离子与沿根牙本质小管向外迁移的腐蚀离子的距离，以寻求在金属过敏的情况下去除铸造柱的指南。首先，我们研究了内部有金属柱的提取的牙齿，其处理历史是使用最高分辨率EPMA知道的。但是，当我们研究牙齿切割表面时，没有可检测的金属离子。然后，我们使用正畸牙齿进行了几种类型的体外实验，以模拟口腔内口腔条件。就我们目前使用的最敏感的机器而言，只有几百千米中的铸造柱迁移到根牙本质中，只有可忽略的铜。我们无法得出结论，从铸造柱中腐蚀的金属离子不可能退出外部根部表面。但是，去除未暴露的铸造柱，在过敏患者中可能比其他疗法的优先级较少，因为将患者在高浓度下暴露于过敏原的可能性较小。需要进行仔细的研究。