Studies on migration of metal ions originated from cast post and antigen presenting ability of periodontal ligament cells.

铸桩源金属离子迁移及牙周膜细胞抗原呈递能力的研究。

• 批准号: 12671875
• 负责人: UOSHIMA Katsumi
• 金额: $ 2.18万
• 依托单位: NIIGATA UNIVERSITY (2002)Tokyo Medical and Dental University (2000-2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671875/
• 关键词: Dental Metal Allergy; Dental alloy; Dentin permeability; Allergen Removal; Metal abutment; 金属性支台装置

We have been seeing allergic patients for more than fourteen years in our metal allergy clinic. Currently, one of our major questions is whether we should remove metal cast post that contains allergens out of allergic patient's mouth, in case of the metal is not directly exposed to the oral cavity. Because there should be certain risks removing cast post out of the tooth. The purpose of this study was to investigate the distance of corroded ions from cast post migrating outward along the root dentinal tubules to seek the guideline for removal of cast post in case of metal allergy.First, we investigated the extracted teeth that had metal post inside and whose treatment histories were known using the highest resolution EPMA. However, there were no detectable metal ions when we investigated the cut surface of the teeth. Then we carried out several types of in vitro experiments simulating intra oral mouth conditions using orthodontically extracted teeth. As far as we found using most sensitive machine we have currently, there were only negligible copper migrated to root dentine from cast post in several hundred micrometer. We could not conclude that there was no possibility for corroded metal ions from cast posts exit the outer root surface. However, the removal of cast posts that are not exposed, out of allergic patients may have less priority than other treatments because it is less likely for the patients to be exposed to the allergen at high concentration.Further careful investigations will be needed.

我们的金属过敏诊所已经接待过敏患者超过14年了。目前，我们的一个主要问题是，如果金属不直接暴露在口腔中，是否应该从过敏患者的口腔中取出含有过敏原的金属铸件。因为从牙齿中取出铸桩是有一定风险的。本研究的目的是研究腐蚀离子沿牙根牙本质小管向外迁移的距离，以寻求金属过敏情况下取下铸造桩的指导原则。首先，我们用最高分辨率的电子探针研究了金属桩内有金属桩的拔除牙齿。然而，当我们调查牙齿的切割表面时，没有检测到金属离子。然后，我们使用正畸拔除的牙齿进行了几种类型的体外实验，模拟口腔内的条件。据我们目前最敏感的机器发现，在几百微米的范围内，只有微不足道的铜从铸型桩迁移到牙本质中。我们不能得出结论，铸造桩的腐蚀金属离子不可能从外牙根表面流出。然而，与其他治疗方法相比，从过敏患者身上移除没有暴露的管型柱的优先程度可能较低，因为患者接触高浓度过敏原的可能性较小。需要进行更仔细的调查。