Establishment of small scale bone augmentation without the reflection of periosteum

无骨膜反射小尺度骨增量的建立

• 批准号: 22659348
• 负责人: UOSHIMA Katsumi
• 金额: $ 2.07万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659348/
• 关键词: 歯科補綴学一般; 歯学; 骨増成; 生体材料; インプラント; 増殖因子

To establish a new technique of small scale bone augmentation for dental implant application without the reflection of periosteum, animal experiments were carried out using mixtures of Biopex-R (α-TCP) and several cytokines. Biopex-R and BMP-2, EGF, FGF-2, PDGF were mixed respectively and applied under rat calvarial periosteum using 18G needle. As a result of histological investigations, mixtures ofBiopex-R and BMP-2, EGF, PDGF showed better bone formation in comparison to Biopex-Ronly.

为了建立一种无骨膜反射的牙种植体小规模植骨修复新技术，用Biopex-R(α-Tcp)和多种细胞因子的混合物进行了动物实验。将Biopex-R分别与BMP-2、EGF、FGF-2、PDGF混合，用18G针在大鼠颅骨骨膜下应用。组织学结果显示，Biopex-R与BMP-2、EGF、PDGF的混合物与单独Biopex-R相比显示出更好的成骨效果。