Infection with New Type Hepatitis Viruses G and TTV, and Oral Malignant Tumors

新型肝炎病毒G、TTV感染与口腔恶性肿瘤

• 批准号: 12671959
• 负责人: TAKATA Yutaka
• 金额: $ 2.05万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671959/
• 关键词: Dental; Hepatitis virus; HGV; TTV; Oral cancer; Oral cyst; Oral surgery; Infection; 肝炎ウィルス; G型; TTV型; 口腔のう腔; B型; C型; 口腔のう胞

Prevalences of infection with new type hepatitis viruses G and transfusion transmitted virus (TTV) as well as with hepatitis B and C were evaluated in association with oral diseases including oral cancers. HCV antibody was more prevalent in patients with oral cancers than in those with oral cysts (8.6% vs. 4.0%), but this difference was disappeared with age adjustment. On the other hand, HBs antigen was more prevalent in patients with oral cysts than in those with oral cancers (2.1% vs. 0%), whether or not adjustment was made for age. No differences in HGV RNA or TTV DNA were found between oral cancers and oral cysts (3.2% vs. 2.8% for HGV RNA, 29.7% vs. 32.1% for TTV DNA ). There were no differences in HBs antigen, HCV antibody, HGV RNA, or TTV DNA between patients with impacted teeth and jaw deformities (1.1% vs. 0% for HBs antigen, 4.1% vs. 3.2% for HCV antibody, 1.8% vs. 0% for HGV RNA, 22.9% vs. 21.4% for TTV DNA). In conclusion, TTV DNA was much more prevalent than the other viruses. No etiological association was found between HCV infection and oral cancer.

评价了新型庚型肝炎病毒和输血传播病毒（TTV）以及B和C型肝炎感染与口腔疾病（包括口腔癌）的相关性。口腔癌患者的HCV抗体比口腔囊肿患者更普遍（8.6%对4.0%），但这种差异随着年龄的调整而消失。另一方面，口腔囊肿患者的HBs抗原比口腔癌患者更普遍（2.1%对0%），无论是否进行了年龄调整。口腔癌和口腔囊肿之间的HGV RNA或TTV DNA没有差异（HGV RNA为3.2%比2.8%，TTV DNA为29.7%比32.1%）。阻生牙和颌骨畸形患者的HBs抗原、HCV抗体、HGV RNA或TTV DNA无差异（HBs抗原1.1% vs. 0%，HCV抗体4.1% vs. 3.2%，HGV RNA 1.8% vs. 0%，TTV DNA 22.9% vs. 21.4%）。总之，TTV DNA比其他病毒更普遍。未发现HCV感染与口腔癌之间的病因学联系。

项目成果

Takata Y, Tominaga K, Naito T, Kurokawa H, Sonoki K, et al.: "Prevalence of hepatitis viral infection in dental patients with impacted teeth or jaw deformities"Oral Surgery Oral Medicine Oral Pathology Oral Radiology. 95(in press). (2003)

Takata Y、Tominaga K、Naito T、Kurokawa H、Sonoki K 等人：“患有阻生牙或下颌畸形的牙科患者中肝炎病毒感染的患病率”口腔外科口腔医学口腔病理学口腔放射学。

Takata Y, Tominaga K, Naito T, Kurokawa H, Sonoki K, et al.: "Prevalence of hepatitis virus infection in dental patients with impacted teeth or jaw deformities"Oral Surgery Oral Medicine Oral Pathology Oral Radiology. 95(in press). (2003)

Takata Y、Tominaga K、Naito T、Kurokawa H、Sonoki K 等人：“患有阻生牙或下颌畸形的牙科患者中肝炎病毒感染的患病率”口腔外科口腔医学口腔病理学口腔放射学。

高田 豊, 下田妙子: "栄養指導マニュアル、改訂3版"南山堂. 176 (2002)

Yutaka Takada、Taeko Shimoda：“营养指导手册，修订第 3 版”Nanzando 176 (2002)。

Takata Y, Fukuda J, Kurokawa H, Nakanishi O: "Electrocariographic findings and history of medical diseases in hospitalized dental patients"Journal of Disability and Oral Health. 3(1). 13-19 (2002)

Takata Y、Fukuda J、Kurokawa H、Nakanishi O：“住院牙科患者的心电图检查结果和医疗疾病史”《残疾与口腔健康杂志》。

Takata Y, Kurokawa H, Tominaga K, Sonoki K, Iwamoto H, et al.: "Disease-specific prevalence of anaemia in adult patients undergoing surgery"Asian Journal of Oral and Maxillofacial Surgery. 14(1). 15-20 (2002)

Takata Y、Kurokawa H、Tominaga K、Sonoki K、Iwamoto H 等人：“接受手术的成人患者贫血的疾病特异性患病率”亚洲口腔颌面外科杂志。