权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Relationships between tooth number and cardiovascular morbidity or total mortality in 8020 study

8020研究中牙齿数量与心血管发病率或总死亡率之间的关系

基本信息

批准号：
15390655
负责人：
TAKATA Yutaka
金额：
$ 4.42万
依托单位：
Kyushu Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390655/
关键词：
elderly 8020 chewing general condition mortality ADL epidemiology tooth 咀嚼機能口腔心血管病死亡 8020研究予後

项目摘要

In 1998, 823 (309 males and 514 females) 80-year-old individuals, each residing in one of three cities, four towns, one village, or one ward in Fukuoka Prefecture, Japan, participated in the present study. 697 of 823 underwent a laboratory blood examination. During the four-year follow-up, 140 individuals (66 males and 74 females) died. Of these, 43 deaths were due to respiratory system including pneumonia, 36 to cancer, and 34 to cardiovascular diseases with strokes.Four-year total mortality was related significantly with chewing ability (P=0.01). Compared with individuals capable of chewing 5-15 foods, a shorter survival period was found among individuals of chewing only 0-4 foods. Multivariate Cox proportional analysis adjusted with gender and ADL also showed a poor survival in individuals chewing only 0-4 foods than in those chewable all 15 foods.Next, only 697 subjects (277 males and 420 females) who underwent blood examination at 80-year were analyzed. During 4-year follow-up, 108 individuals (58 males and 50 females) died. Cox analysis with adjustment for not only gender and ADL but also smoking, BMI, BP, and serum concentrations of cholesterol, glucose, and albumin also demonstrated 2.38 times (P=0.03) higher mortality in individual chewable only 0-4 foods than in those chewing all 15 foods. Similarly, in 5.5-year follow study, subjects who were able to chew 0-4 foods had 2.8 times (P=0.005) higher mortality than those capable to chew all 15 foods, using Logistic regression analysis.Additionally, by logistic regression analysis, functional dependency was 7.532 times more prevalent in individuals capable of chewing 4 foods or fewer, and 3.333 times more prevalent in those chewing 5-9, than in those chewing all 15 items.Chewing ability may be independently related with survival and functional status in 80-year olds.

在1998年，823名（309名男性和514名女性）80岁的个体，每个人都居住在日本福冈县的三个城市，四个城镇，一个村庄，或一个病房之一，参加了本研究。823人中有697人接受了实验室血液检查。在四年的随访中，140人（66名男性和74名女性）死亡。其中43例死于呼吸系统疾病（包括肺炎），36例死于癌症，34例死于心血管疾病（包括中风），4年总死亡率与咀嚼能力显著相关（P=0.01）。与能够咀嚼5-15种食物的个体相比，仅咀嚼0-4种食物的个体的存活期较短。调整性别和ADL的多变量考克斯比例分析也显示，咀嚼0-4种食物的个体的生存率低于咀嚼所有15种食物的个体。在4年的随访中，108人（58名男性和50名女性）死亡。考克斯分析不仅调整了性别和ADL，还调整了吸烟、BMI、BP和胆固醇、葡萄糖和白蛋白的血清浓度，结果显示，仅咀嚼0-4种食物的个体死亡率比咀嚼所有15种食物的个体高2.38倍（P=0.03）。同样，在5.5年的随访研究中，能够咀嚼0-4种食物的受试者有2.8次（P=0.005）死亡率高于能够咀嚼所有15种食物的人。此外，通过Logistic回归分析，能够咀嚼4种或更少食物的人的功能依赖性是其他人的7.532倍，咀嚼5-9个项目者比咀嚼全部15个项目者多3.333倍。咀嚼能力可能与80岁奥尔兹的生存和功能状态独立相关。