Protective effects of sesame lignans on senescence accelerate brain in rats and mice

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Recent studies have shown that oxidative stress is important in the pathogenesis of Alzheimer disease and high doses of vitamin E to Alzheimer disease patients improved the disease state. β-Amyloid (Aβ), which is found abundantly in the brains of Alzheimer disease patients, is cytotoxic to neurons and has a central role in the pathogenesis of the disease. There was a paper to report protective effects of α-tocopherol (α-Toc) on Aβ(1-42)-induced learing and memory deficits in rats. Our previous studies showed that sesame seed and its lignans elevated α-Toc concentrations in brain as well as plasma and liver. In this study, we investigated whether the protective effects of sesame seed on senescence accelerated brain were observed in Aβ infused rats and senescence accelerated mouse (SAM)P8. In Experiment 1, we examined α-Toc concentrations in cerebrum, cerebellum, brain stem and hippocampus in brain and TEARS in brain in rats fed diets containing 500 mg/kg α-Toc alone and 50 mg/kg α-Toc with sesame seed. In Experiment 2, learning and memory in radial maze task were examined in rats infused Aβ and fed diets 50 mg/kg α-Toc alone and 50 mg/kg α-Toc with sesame seed. In Experiment 3, passive avoidance task was examined in SAMP8 mice fed the same diets in Exp.2. We obtained the results that sesame seed group showed higher concentrations of α-Toc in all parts of brain examined compared to 500 mg/kg α-Toc group and lower concentration of TEARS in brain, however we could not observe that sesame seed improved learning and memory on senescence accelerated brain in rats and mice.