Effect of α-tocopherol and sesame lignans on tocotrienol metabolism in rats and mice

α-生育酚和芝麻木脂素对大鼠和小鼠生育三烯酚代谢的影响

• 批准号: 14380046
• 负责人: YAMASHITA Kanae
• 金额: $ 6.27万
• 依托单位: Sugiyama Jogakuen University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14380046/
• 关键词: Vitamin E; α-tocopherol; α-tocotrienol; γ-tocotrienol; sesame lignan; skin; UVB; antioxidant; 脂肪組織; ラット; ヘアレスマウス; 血漿リポたんぱく質; 肝臓; ラツト

It is well known that α -tocopherol has the highest vitamin E activity because it has the highest affinity with α-TTP in the liver. We found that α-tocopherol enhances the α-tocotrienol metabolism but not the γ-tocotrienol metabolism in rats. We observed that sesame seed and its lignans produced higher concentrations of vitamin E (tocopherols and tocotrienols) in the animal body. We could prove that the primary cause of high vitamin E concentrations in rats fed sesame seed is that sesame lignans inhibit the degradation of vitamin E to CEHC. We also found that tocotrienol distribution in the animal body is different from that of tocopherol, and that tocotrienol is present specifically in the skin and adipose tissues. Dietary tocotrienol accumulated in the skin prevents oxidative damage induced by UVB irradiation and is a more powerful antioxidant than α-tocopherol. Sesame seed and its lignans induce higher tocotrienol concentrations in the skin and adipose tissues, and act together with tocotrienol to prevent oxidative damage induced by UVB irradiation.

众所周知，α -生育酚具有最高的维生素E活性，因为它与肝脏中的α-TTP具有最高的亲和力。我们发现，α-生育酚促进大鼠α-生育三烯酚代谢，但不促进γ-生育三烯酚代谢。我们观察到，芝麻籽及其木脂素在动物体内产生较高浓度的维生素E（生育酚和生育三烯酚）。我们可以证明，芝麻籽喂养的大鼠中维生素E浓度高的主要原因是芝麻木脂素抑制维生素E降解为CEHC。我们还发现生育三烯酚在动物体内的分布与生育酚不同，生育三烯酚特异性地存在于皮肤和脂肪组织中。在皮肤中积累的膳食生育三烯酚可防止UVB照射引起的氧化损伤，是比α-生育酚更强大的抗氧化剂。芝麻籽及其木脂素可诱导皮肤和脂肪组织中更高的生育三烯酚浓度，并与生育三烯酚共同作用，防止UVB照射引起的氧化损伤。

项目成果

Kanae Yamashita, Saiko Ikeda, Yoshie Iizuka, Ikuo Ikeda: "Effect of Sesaminol on Plasma and Tissue □-Tocopherol and □-Tocotrienol Concentrations in Rats Fed a Vitamin E Concentrate Rich in Tocotrienols,"Lipids. Vol.37, No.4. 351-358 (2002)

Kanae Yamashita、Saiko Ikeda、Yoshie Iizuka、Ikuo Ikeda：“喂食富含生育三烯酚的维生素 E 浓缩物后，芝麻素酚对血浆和组织中 □-生育酚和 □-生育三烯酚浓度的影响”，第 37 卷，第 4 期。 351-358 (2002)

Saiko Ikeda, Tomoko Tohyama, Kanae Yamashita: "Dietary Sesame Seed and Its Lignans Inhibit 2,7,8-Trimethyl-2(2'-carboxyethyl) -6-hydroxychroman Excretion into Urine of Rats Fed γ-Tocopherol."Journal of Nutrition.. Vol.132, No.5. 961-966 (2002)

Saiko Ikeda、Tomoko Tohyama、Kanae Yamashita：“膳食芝麻及其木脂素抑制 2,7,8-三甲基-2(2-羧乙基) -6-羟基色满排泄到喂食 γ-生育酚的大鼠尿液中。”营养杂志.. 第 132 卷，第 961-966 号（2002 年）

Dietary Sesame Seed and Its Lignans Inhibit 2,7,8-Trimethyl-2(2'-carboxyethyl)-6-hydroxychroman Excretion into Urine of Rats Fed γ-Tocopherol.

膳食芝麻及其木脂素抑制 2,7,8-三甲基-2(2-羧乙基)-6-羟基苯并二氢吡喃在喂食 γ-生育酚的大鼠尿液中的排泄。

• 发表时间: 2002
• 期刊: J.Nutr. Vol.132, No.5
• 作者: Saiko Ikeda;Tomoko Tohyama;Kanae Yamashita
• 通讯作者: Kanae Yamashita

Enhancing Effects on Vitamin E Activity of Sesame Lignans.

芝麻木脂素对维生素 E 活性的增强作用。

• 发表时间: 2004
• 期刊: J Clin.Biochem.Nutr. Vol.35,No.1
• 作者: Kanae Yamashita

Kanae Yamashita, Saiko Ikeda, Yoshie Iizuka, Ikuo Ikeda: "Effect of Sesaminol on Plasma and Tissue α-Tocopherol and α-Tocotrienol Concentrations in Rats Fed a Vitamin E Concentrate Rich in Tocotrienols"Lipids. Vol.37, No.4. 351-358 (2002)

Kanae Yamashita、Saiko Ikeda、Yoshie Iizuka、Ikuo Ikeda：“芝麻素对喂食富含生育三烯酚的维生素 E 浓缩物的大鼠血浆和组织 α-生育酚和 α-生育三烯酚浓度的影响”，第 37 卷，第 4 期。 -358 (2002)