Mechanism of enhancing vitamin E activity by sesame seed or its lignans
Mechanism of enhancing vitamin E activity by sesame seed or its lignans
批准号:
09680043
负责人:
YAMASHITA Kanae
金额:
$2.05万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998
中文摘要
通过三个实验研究了芝麻籽或其木脂素增强维生素E活性的机制。在实验1中,我们检测了饲喂对照饲料或含有20%芝麻籽的饲料的大鼠肝脏中α-生育酚转移蛋白(α-TTP)的浓度。使用Arai博士(DEP.)捐赠的免疫抗体,用免疫抗体方法评估药物浓度。东京大学药理学教授)。在实验2中,我们观察了芝麻木脂素(芝麻素和芝麻酚)对0.5%DHA喂养大鼠产生的过氧化脂质的抑制作用。在喂食DHA的大鼠中,血浆、肝脏和脑中的过氧化脂质水平显著增加,而血浆和肝脏中的α-生育酚水平下降,但脑中没有。芝麻素和芝麻酚的添加显著抑制了过氧化脂质的产生,并提高了血浆、肝脏和大脑中的α-生育酚水平。这些作用与芝麻素或芝麻酚几乎相同。在实验3中,比较了喂食只含有g-生育酚的芝麻籽的大鼠和喂食伽马-生育酚的大鼠大脑中的伽马-生育酚浓度。饲喂芝麻籽组大鼠脑内γ-生育酚含量较高,而饲喂γ-生育酚组小鼠脑内γ-生育酚含量极低。此外,饲喂α-生育酚芝麻的大鼠脑内α-生育酚浓度高于不喂芝麻的对照组。
英文摘要
Mechanisms enhancing vitamin E activity by sesame seed or its lignans were investigated in three experiments.In experiment 1 we examined the concentration of the liver alpha-tocopherol transfer protein (alphaTTP) in the liver of rats fed a control diet or a 20% sesame seed containing diet. The concentration was evaluated by the immuno-antibody method using immuno-antibodies kindly donated by Dr. Arai (Dept. of Pharmacology, Tokyo University). The results showed no difference in the concentrations of alphaTTP between control rats and sesame seed fed rats.In experiment 2 we investigated the suppressing effect of sesame lignans (sesamin and sesaminol) on lipid peroxides produced by 0.5 % DHA feeding in rats. In rats fed DHA, lipid peroxide levels significantly increased in the plasma, liver and brain, and alpha-tocopherol levels decreased in the plasma and liver but not the brain. The addition of sesamin and sesaminol significantly inhibited production of lipidperoxide and raised alpha-tocopherol levels in the plasma, liver and brain. These effects were nearly the same with either sesamin or sesaminol.In experiment 3, gamma-tocopherol concentration in the brain of rats fed sesame seed, which contains only g-tocopherol, was compared to that of rats fed gamma-tocopherol. A high gamma-tocopherol concentration was found in tha sesame seed fed group, but negligible amounts of gamma-tocopherol in brain were found in the gamma-tocopherol-fed group. Further, the concentration of alpha-tocopherol in the brain of rats fed sesame seed with alpha-tocopherol was higher than that of control group without sesame seed.
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Nonaka, M., Yamashita, K., Iizuka, Y., Namiki, M.and Sugano, M.: "Effects dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol." Biosci.Biotec.Biochem.61. 836-839 (1997)
Nonaka, M.、Yamashita, K.、Iizuka, Y.、Namiki, M.和 Sugano, M.:“在给予乙醇的大鼠中,饮食芝麻素酚和芝麻素对类二十烷酸的产生和免疫球蛋白水平的影响。”
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通讯作者:
K.Yamashita: "Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention" The Royal Society of Chemistry, 449 (1996)
K.Yamashita:“动脉粥样硬化和癌症预防中的天然抗氧化剂和食品质量”英国皇家化学学会,449 (1996)
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K.Yamashita: "Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention" The Royal Society of Chemistry, 4 (1996)
K.Yamashita:“动脉粥样硬化和癌症预防中的天然抗氧化剂和食品质量”英国皇家化学学会,4 (1996)
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山下かなへ: "血漿・肝臓トコフェロール濃度と胆汁トコフェロール濃度" ビタミンE研究の進歩VIII. 35-39 (1998)
Kanae Yamashita:“血浆/肝脏生育酚浓度和胆汁生育酚浓度”维生素 E 研究进展 VIII 35-39 (1998)
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山下かなへ: "ゴマその科学と機能性" 日本ゴマ科学会並木満夫編 丸善プラットネット, 268 (1998)
Kanae Yamashita:“芝麻的科学与功能”,并木光雄主编,日本芝麻学会,Maruzen Platnet,268(1998)
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共 14 条
Effect of sesame seed on tocopherol metabolism in α-tocopherol transfer protein knock out mice
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批准号:17300240
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.54万
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财政年份:2005
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负责人:YAMASHITA Kanae
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依托单位:
Effect of α-tocopherol and sesame lignans on tocotrienol metabolism in rats and mice
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批准号:14380046
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.27万
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财政年份:2002
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负责人:YAMASHITA Kanae
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依托单位:
Protective effects of sesame lignans on senescence accelerate brain in rats and mice
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批准号:12680143
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2000
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负责人:YAMASHITA Kanae
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依托单位:
Mechanism of enhancing vitamin E activity by sesame seed or its lignans
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批准号:07680051
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:YAMASHITA Kanae
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依托单位:
Mechanism of synergistic effect on sesame lignans and tocopherols
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批准号:05680040
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.47万
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财政年份:1993
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负责人:YAMASHITA Kanae
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依托单位:
Anti-Aging Effects of Natural Antioxidants on Senescence Accelerated Mouse (SAM)
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批准号:63580072
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1988
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负责人:YAMASHITA Kanae
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依托单位:
海外基金