Development of a quick diagnosis of Haemophilus influenzea Which induces Guillain- Barre syndrome.

开发出诱发格林-巴利综合征的流感嗜血杆菌快速诊断方法。

• 批准号: 13307010
• 负责人: NODA Masatoshi
• 金额: $ 31.12万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13307010/
• 关键词: Guillain-Barre syndrome; Haemophilus influenza; Ganalioside GM1; ganglioside GM1-like structure; cytotoxin; ギラン・バレー症候群(GBS); Campylobacter jejuni; 急性下痢症; Haemophilus influenzae; 呼吸器感染症; 上気道炎; 抗カングリオシドGM1; ガングリオシドGM; リポ多糖; 神経障害; ガングリオシドGQ1b

It has been reported recently that Haemophilus influenzas can elicit an axonal form of Guillain-Barre syndrome. It is very important to know which Haemophilus influenzas can induce the Guillain-Barre syndrome. Group A of Haemophilus influenzae which were isolated from patients with Guillain-Barre syndrome were characterized and compared with Group B of Haemophilus influenzae which were isolated from patients without Guillain-Barre syndrome. It is concluded that Haemophilus influenzae in Group A has a ganglioside GM1-like structure and a cytotoxin whose molecular weight is approximately 40,000. The ganglioside GM1-like structure and the cytotoxin may be the most important characters of Haemophilus influenzae which can induce the Guillain-Barre syndrome. By using these two characters we are now developing a quick diagnosis of Haemophilus influenzae which can induce the Guillain-Barre syndrome.

最近有报道称流感嗜血杆菌可引起轴索型格林-巴利综合征。了解哪些流感嗜血杆菌可诱发格林-巴利综合征是非常重要的。对分离自格林-巴利综合征患者的A群流感嗜血杆菌和分离自非格林-巴利综合征患者的B群流感嗜血杆菌进行了比较。结论：A组流感嗜血杆菌具有神经节苷脂GM 1样结构和分子量约为40，000的细胞毒素。神经节苷脂GM 1样结构和细胞毒素可能是流感嗜血杆菌引起格林-巴利综合征的重要特征。利用这两个特征，我们正在开发一种快速诊断流感嗜血杆菌，它可以引起格林-巴利综合征。

项目成果

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Kuwabara S.等人：“使用 IgG 抗 GM1 抗体静脉注射免疫球蛋白治疗吉兰-巴利综合征”肌肉神经。

Sakakibara R.et al: "Autonomic dysreflexia due to neurogenic bladder dysfunctions;an unusual presentation of spinal cord sarcoidosis"J Neurosury Psychiatry. 71. 819-820 (2001)

Sakakibara R.等人：“神经源性膀胱功能障碍导致的自主神经反射异常；脊髓结节病的异常表现”J Neurosury Psychiatry。

Kuwabara S., et al.: "Indicators of rapid clinical recovery in Guillan-Barre syndrome"J Neurol Neurosurg Psychiatry. 70. 560-562 (2001)

Kuwabara S. 等人：“吉兰-巴利综合征临床快速恢复的指标”J Neurol Neurosurg Psychiatry。

Kuwabara S. et al.: "Hyperreflexia in axonal Guillain-Bane syndrome subsequent to Campylobacter jejuni enteritis"J Neurol Sci. 199. 89-92 (2002)

Kuwabara S.等人：“空肠弯曲菌肠炎后轴突格林-贝恩综合征中的反射亢进”J Neurol Sci。

Suzuki K, Kuwabara S, et al.: "Fine specificities of anti-LM1 IgG antibodies in Guillain-Barre syndrome"J Neurol Sci.. 195. 145-148 (2002)

Suzuki K、Kuwabara S 等人：“格林-巴利综合征中抗 LM1 IgG 抗体的精细特异性”J Neurol Sci.. 195. 145-148 (2002)