Risk Evaluation for the Incidence of Congenital Hypothyroidism in Prenatal Multiple Exposure to Toxic Chemical Compounds

产前多次接触有毒化合物导致先天性甲状腺功能减退症发生的风险评估

• 批准号: 13308031
• 负责人: NAGAYAMA Junya
• 金额: $ 26.54万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13308031/
• 关键词: PCDDs; PCDFs; PCBs; Organochlorine Pesticides; Toxic Chemical Compounds; Prenatal Exposure; Congenital Hypothyroidism; Risk Evaluation; 胎児期復号曝露

Serum concentrations (Mean±S.D.) of TSH, fT_3 and fT_4, respectively, were 35.4±49.7 μIU/ml, 3.07±0.89 pg/ml and 1.09±0.32 ng/dl in 64 (male:38,female:26) positive neonates in the mass-screening for congenital hypothyroidism or cretinism. In 108 (male:58,female:50) negative neonates in this mass-screening, the respective serum concentrations were 8.56±5.62 μIU/ml, 3.60±0.84 pg/ml and 2.46 ± 0.67 ng/dl. Concentrations of TSH were significantly higher in the positive neonates than in the negative neonates, and those of fT_3 and fT_4 lower in the former ones than in the latter ones.Contamination levels (Mean±S.D., neonates with cretinism : normal neonates) of the organochlorine compounds in the breast milk samples which were collected within 4 weeks after childbirth were as follows: Dioxins (TEQ-pg/g);0.52±0.40:0.28±0.15,PCBs (ng/g);2.6±2.:1.5±1.3,DDT (ng/g) ;7.2±6.8:3.7±3.7,HCH (ng/g);2.7±3.4:1.3±1.2,Chlordane (ng/g);1.6±1.7:0.76±0.68 and HCB (ng/g);0.30±0.22:0.17±0.18. According to these analytical results, concentrations of the organochlorine compounds except HCH in the breast milk were significantly higher in the mothers who gave birth to neonates with congenital hypothyroidism than in those who gave birth to normal neonates.Consequently, this study suggests higher prenatal multiple exposures to such organochlorine compounds may cause congenital hypothyroidism in Japan.

血清浓度（平均值±S.D.）先天性甲减或克汀病筛查阳性新生儿64例（男38例，女26例），TSH、fT_3、fT_4分别为35.4±49.7 μIU/ml、3.07± 0.89pg/ml、1.09± 0.32ng/dl。108例（男58例，女50例）筛查阴性新生儿，血清中的浓度分别为8.56±5.62 μIU/ml、3.60±0.84 pg/ml和2.46 ± 0.67 ng/dl。TSH阳性组新生儿的TSH浓度明显高于阴性组，fT_3和fT_4则明显低于阴性组。患有克汀病的新生儿：在产后4周内采集的母乳样品中，有机氯化合物的检出率分别为：二恶英（TEQ-pg/g）：0.52±0.40：0.28± 0.15，PCBs（ng/g）：2.6±2.：滴滴涕：滴滴涕（1.5± 1.3 ng/g）;六六六：六六六（7.2±6.8 ng/g）;滴滴涕：六六六（2.7± 3.4 ng/g）;六六六：六六六（1.6±1.7 ng/g）;六六六：六六六（0.30±0.22 ng/g）。根据这些分析结果，母乳中有机氯化合物（HCH除外）的浓度在生下先天性甲状腺功能减退症新生儿的母亲中明显高于生下正常新生儿的母亲，因此，本研究表明，在日本，产前多次接触此类有机氯化合物可能会导致先天性甲状腺功能减退症。

项目成果

残留性有機汚染物質(POPs)による愛媛県在住初産婦の母乳汚染

由于持久性有机污染物（POPs），爱媛县一位初为人母的母乳受到污染

• 发表时间: 2004
• 期刊: 環境科学会誌 17
• 作者: 國末達也

Nagayama J. et al.: "Thyroid hormone status in Japanese infants lactationally exposed to organochlorine pesticides, PCBs and dioxins"Organohalogen Compounds. 53. 140-144 (2001)

Nagayama J. 等人：“哺乳期接触有机氯杀虫剂、多氯联苯和二恶英的日本婴儿的甲状腺激素状态”有机卤素化合物。

Contamination by persistent organic pollutants (POPs) in human breast milk collected from primiparas in Ehime prefecture

爱媛县初产妇母乳中持久性有机污染物（POPs）污染

• 发表时间: 2004
• 期刊: Environmental Science 17
• 作者: T.Kunisue;M.Someya;M.Watanabe;T.Toyota;Y.Kuroda;J.Nagayama;S.Tanabe
• 通讯作者: S.Tanabe

J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa, T.Matsueda, et al.: "Sexual distinction in effects of perinatal exposure to organochlorine pesticides, PCBs and dioxins on frequency of sister chromatid exchanges in Japanese infants"Organohalogen Compounds. 65. 24

J.Nagayama、H.Tsuji、T.Iida、R.Nakakawa、T.Matsueda 等人：“围产期接触有机氯农药、多氯联苯和二恶英对日本婴儿姐妹染色单体交换频率影响的性别差异”有机卤素

J.Nagayama et al.: "Frequency of sister chromatid exchanges in Japanese infants lactationally exposed to organochlorine pesticides and dioxins"Organohalogen Compounds. 55. 429-432 (2002)

J.Nagayama 等人：“哺乳期暴露于有机氯杀虫剂和二恶英的日本婴儿中姐妹染色单体交换的频率”有机卤素化合物。