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Dwelling habitat and expansion of fungi related with zoonoses

与人畜共患疾病有关的真菌的栖息地和扩张

基本信息

批准号：
13660331
负责人：
TAKATORI Kosuke
金额：
$ 2.18万
依托单位：
National Institute of Health Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

Recently, various mycotic zoonoses of human transmitted from domestic animals are taken a serious matter. The outbreak of these diseases under many complicated circumstances existed between the community of human and animals. It is, however, unknown that the dwelling habitat and expansion of fungi related with pathogenic and opportunistic fungi between human and animals like pets. Therefore, the study was planned to investigate the relation between zoonoses and pathogenic or opportunistic fungi. Each theme was as followings ; 1) The fungal distribution in dwelling environment, 2) The occurrence of infectious diseases caused by fungi in dwelling environment, 3) The ecological and pathogenic investigation of environmental fungi and 4) The biological and cytological activities of fungi. As the epidemiological study of mycotic zoonoses is delayed compared with other microbes, the fundamental and applied studies on mycotic zoonoses must be moreover developed and concluded the essential prob … More lems of this disease. According to this purpose, the author has actively preceded the dwelling habitat and expansion of environment fungi related with zoonoses such as dermatophytes, keratinophilic fungi, Aspergillus, Fusarium, Mucor, Rhizopus, Absidia and yeasts.The relation between animal free (A-) and animal breeding (A+) dwelling in indoor was not significantly certificated in point of the CPU. Namely, the former was CPU 2.3X 10^4 - 7.8×10^6/ g housedust. The latter was CPU 1.7×10^4 -8.6×10^6/g house dust. The dominant fungi between A- and A+ dwellings were almost similar as Aspergillus, Penicillium, Eurotium, Wallemia, Cladosporium, Alternaria and Aspergillus, Penicillium Cladosporium, Eurotium, Fusarium, respectively. On the contrary, the fungi related with zoonoses apparently differed from that the former was only Aspergillus fumigatus and Fusarium and the latter was broad distribution as A. fumigatus, A.flavus, Geotrichum, Scopulariopsis, Microsporum gypseum, Chrysosporium and Fusarium.By the hair baiting technique tested with house dust, many kinds of keratinophilic fungi were distributed in A+ rather than A-dwelling.The biological activities of fungi related with zoonoses in dwelling environments were confirmed that the protease and other enzyme productivity was high level. Less

近年来，由家畜传播的各种人畜共患霉菌性人畜共患病日益受到重视。这些疾病的暴发在许多复杂的情况下都存在于人与动物之间。然而，目前尚不清楚与致病真菌和机会真菌相关的真菌在人与宠物等动物之间的栖息地和扩展情况。因此，本研究旨在探讨人畜共患病与致病真菌或条件真菌之间的关系。每个主题包括：1)居住环境中真菌的分布，2)居住环境中真菌引起的传染病的发生，3)环境真菌的生态和病原学调查，4)真菌的生物学和细胞学活动。与其他微生物相比，真菌人畜共患病的流行病学研究相对滞后，必须进一步开展对真菌人畜共患病的基础和应用研究，并总结出必要的…。更多的这种疾病的症状。为此，笔者积极研究了与人畜共患病有关的环境真菌，如皮癣真菌、嗜角质真菌、曲霉、镰刀菌、毛霉、根霉、黑曲霉和酵母菌等的栖息地和扩展，但从中央处理器的角度看，无动物(A-)与动物繁育(A+)在室内栖息的关系没有得到显著的证明。即前者为CPU2.3×10^4-7.8×10^6/g室内粉尘。后者为CPU1.7×104~8.6×106/g室内粉尘。A-和A+居民点间的优势真菌分别为曲霉属、青霉属、木霉属、壁霉属、枝孢霉属、交链孢属和曲霉属、青霉属、木霉属、镰刀菌属。与人畜共患病相关的真菌明显不同于前者只有烟曲霉和镰刀菌，后者广泛分布于烟曲霉属、黄曲霉属、地霉属、干酪属、石膏小孢子菌、黄孢霉属和镰刀菌属。通过室内粉尘诱发法试验，发现A+居室中有多种嗜角质真菌分布，而不是A居室。较少