Diversity of mycotic zoonoses and the elucidation of the clinical symptom

人畜共患真菌病的多样性及其临床症状的阐明

• 批准号: 15580282
• 负责人: TAKATORI Kosuke
• 金额: $ 2.37万
• 依托单位: National Institute of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15580282/
• 关键词: zoonoses; dwelling environment; diversification; infectious agent; dispersal; pathogenic fungi; dermatophytosis; host-parasite specificity; 輸入真菌症; 日和見感染; 深在性真菌症; 皮膚糸状菌; 病原性因子

Mycotic zoonoses caused by opportunistic fungi in dwelling ace seriously important problem as well as public health. Therefore, the authors were investigated on the mycology, ecology, epidemiology and clinical pathology of mycotic zoonoses. The diversity of mycotic zoonoses caused by pathogens was extremely progressing. Especially the investigation in this work was carried out the previous results which reported in other papers. The results were showed as followings ;(1)Fungal distribution in dwellings : The fungi were mainly distributed in Mucorales as Rhizopus, Absidia, Mucor, Martierella, dematious hyphomycetes as Exophiala, Aureobasidium around wet environments as like bath room, lavatory kitchen. Emericelh was isolated from dusts, Tatami and close which was somewhat dry area. Candida was isolated from human and animal surface or mucous membrane, and also isolated from clothes-changing room and bath room.(2)The diversity of mycotic zoonoses : With the pet clinics, the authors were sampling with the specimens from the disorderand isolated from the pathogens. The main mycotic diseases were dermatophytoses in this country and the following diseases were Aspergillosis, Zygomycoses, Fusariosis, Candidiosis and Cryptococcosis. The opportunistic pathogens were gradually increasing in dwelling environments like as the interurban buildings rather than rural areas.(3)The biological and epidemiological studies in the pathogens : The pathogens had a biological activities like the producibility of extracellular metabolites in which included proteolytic enzyme. The high proteolytic activities were showed by Emericella nidulans, Aspergillus fumigatus, A.terreus and Scopulariopsis. Furthermore, the zygomycetes, Scedosporium, Emericella and Aspergillus fumigatus showed the hemolytic activities.This investigation on the mycotic zoonoses and epidemiological surveillance apparently suggested the available information in public health and also dwelling environments.

由条件致病真菌引起的人畜共患病是人类面临的重大公共卫生问题。为此，作者对人畜共患病的真菌学、生态学、流行病学和临床病理学进行了研究。由病原体引起的人畜共患病的多样性正在极大地发展。特别是本工作的研究是在前人研究成果的基础上进行的。结果表明：（1）住宅内真菌分布：在浴室、厕所、厨房等潮湿环境中，真菌主要分布在毛霉目（Mucorales）的根霉属（Rhizopus）、犁头霉属（Absidia）、毛霉属（Mucor）、Martierella等，暗色丝孢菌属（Dematious Hyphomycetes）的外瓶霉属（Exophiala）、短梗霉属（Aureobasidium）等。Emericelh与灰尘隔离，榻榻米和关闭这是有点干燥的地区。念珠菌主要从人、动物体表或粘膜分离，也可从更衣室、浴室分离。（2）人畜共患病的多样性：结合宠物门诊，采集病料，分离病原体。我国真菌病以皮肤癣菌病为主，其次为曲霉病、接合菌病、镰刀菌病、念珠菌病和隐球菌病。条件致病菌在居住环境中逐渐增多，如城市间的建筑物，而不是农村地区。（3）病原菌的生物学和流行病学研究：病原菌具有产生胞外代谢产物等生物学活性，其中蛋白水解酶是主要的代谢产物。结果表明，构巢裸孢菌、烟曲霉、土曲霉和帚霉具有较高的蛋白水解活性。此外，放线菌、Scedosporium、Emericella和Aspergillus fumigatus等也表现出溶血活性。

项目成果

獣医領域からみた人獣共通真菌症の問題点

从兽医角度看人畜共患真菌病问题

• 发表时间: 2003
• 期刊: 真菌誌 44
• 作者: 高鳥浩介;相原真紀;高鳥浩介ら
• 通讯作者: 高鳥浩介ら

微生物汚染についての考え方

关于微生物污染的思考

• 发表时间: 2003
• 期刊: IBEC 24
• 作者: 高鳥浩介;相原真紀;高鳥浩介ら;谷口正実ら;土肥友恵ら;高鳥浩介ら;高鳥浩介ら
• 通讯作者: 高鳥浩介ら

Ayako Sakai, Yutaka Kikuchi, Sasashi Muroi, Tohru Masui, Chie Furuhata, Eriko Uchida, Kosuke Takatori, Ken-ichi Tanamoto: "Overexpression of NP95 mRNA by tumor promotes in the promotion phase of a two-stage BALB/3T3 cell transformation assay"Biol.Pharm.Bu

Ayako Sakai、Yutaka Kikuchi、Sasashi Muroi、Tohru Masui、Chie Furuhata、Eriko Uchida、Kosuke Takatori、Ken-ichi Tanamoto：“在两阶段 BALB/3T3 细胞转化测定的促进阶段，肿瘤促进 NP95 mRNA 的过度表达”

The Influences of β-Glucan Associated with BMP-7 on MC3T3-E1 Proliferation and Osteogenic Differentiation

β-葡聚糖联合BMP-7对MC3T3-E1增殖和成骨分化的影响

• 发表时间: 2005
• 期刊: Key Engineering Materials 288-289
• 作者: D.H.Lee;D.-W.Han;B.J.Park;H.S.Baek;K.Takatori;M.Aihara;K.Tsubaki;J.-C.Park
• 通讯作者: J.-C.Park

Fungal sterilization using microwave-induced argon plasma at atmospheric pressure

在大气压下使用微波诱导氩等离子体进行真菌灭菌

• 发表时间: 2004
• 期刊: Journal of Microbiology and Biotechnology 14
• 作者: T.Hasegawa;Y.Yoshida;J.Kosuge;T.Haga;Y.Goto;T.Shinjo;K.Uchida;R.Yamaguchi;S.Takeyama;K.Takatori;高鳥浩介;高鳥浩介;高鳥浩介ら;Jong Chul Park et al.
• 通讯作者: Jong Chul Park et al.