Spatio-Temporal Analysis of Synchronous Oscillatory Activities in Visual System

视觉系统同步振荡活动的时空分析

• 批准号: 13831011
• 负责人: ITO Hiroyuki
• 金额: $ 2.3万
• 依托单位: Kyoto Sangyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13831011/
• 关键词: unitary event; synchronus firing; spike synchrony; lateral geniculate nucleus; visual cortex; oscillatory activities; tetrode; correlated firing; 視覚情報処理; 多細胞同時記録; 多側膝状体; 時空間解析; スパイク統計

Several studies have shown that cells in the visual cortex (A17) of the cat display stimulus-evoked oscillatory firings (30-60Hz) and synchronization among multiple cells. Previously we reported that the cells in the lateral geniculate nucleus (LGN) also showed stimulus evoked synchronous oscillatory firings of higher frequency range (60-100Hz). The difference in their frequency ranges suggested that the oscillatory activity in the cortex was not likely to derive from that in the LGN. On the other hand, Gray et al. reported a transient nature of the synchronization of the oscillatory local field potentials in the cortex, that is, the transition between asynchronous and synchronous states could occur within a trial duration. For further comparison of the synchronization between the two areas, we investigated whether such temporal modulation (non-stationarity) exists also in the -synchronization in the LGN. Since the traditional method of the cross-correlogram loses any information on the non-stationarity by the temporal averaging ovei-the trial duration, we adopted the unitary event (UE) analysis to trace the dynamics of the spike synchrony. We found that also in the LGN, a reasonable portion of synchronous activities was non-stationary even under the presentation of the stationary spot stimulus. The modulation of the number of the UEs had apparently different time scale (less than a few hundred milliseconds) from the rate modulations of the two cells. This result may suggest that the synchrony plays a different functional role from the firing rate in the visual information processing. Furthermore, the unitary event analysis was applied to the spike trains of individual trials. We found a rather large variability and transiency in both the magnitude and the duration of the unitary events over different trials.

多项研究表明，猫视觉皮层 (A17) 中的细胞表现出刺激引起的振荡放电 (30-60Hz) 以及多个细胞之间的同步。之前我们报道过外侧膝状核（LGN）中的细胞也表现出刺激诱发的更高频率范围（60-100Hz）的同步振荡放电。它们频率范围的差异表明，皮质中的振荡活动不太可能源自 LGN 中的振荡活动。另一方面，格雷等人。报道了皮层中振荡局部场电位同步的瞬态性质，即异步和同步状态之间的转换可能在试验持续时间内发生。为了进一步比较两个区域之间的同步，我们研究了这种时间调制（非平稳性）是否也存在于 LGN 的同步中。由于传统的互相关图方法通过试验持续时间的时间平均而丢失了关于非平稳性的任何信息，因此我们采用酉事件（UE）分析来跟踪尖峰同步的动态。我们还发现，在 LGN 中，即使在呈现静止点刺激的情况下，同步活动的合理部分也是非静止的。 UE数量的调制与两个小区的速率调制具有明显不同的时间尺度（小于几百毫秒）。这一结果可能表明同步性在视觉信息处理中与放电率发挥着不同的功能作用。此外，单一事件分析应用于各个试验的尖峰序列。我们发现不同试验中单一事件的幅度和持续时间都存在相当大的变异性和短暂性。

项目成果

銅谷賢治, 伊藤浩之, 藤井宏, 塚田稔: "脳の情報表現-ニューロン・ネットワーク・数理モデル"朝倉書店. 230 (2002)

Kenji Doya、Hiroyuki Ito、Hiroshi Fujii、Minoru Tsukada：“大脑中的信息表示 - 神经元网络数学模型”朝仓书店 230 (2002)。

A.Hirata, P.Maldonado, C.Gray, H.Ito: "Unitary Event Analysis of Synchronous Activities in Cat LGN"Soc.Neurosci.Abstr. 28. 352.14 (2002)

A.Hirata、P.Maldonado、C.Gray、H.Ito：“Cat LGN 中同步活动的单一事件分析”Soc.Neurosci.Abstr。

伊藤浩之: "脳内の同期活動と認知情報処理"Brain Medical. vol.15,No.2. 37-44 (2003)

Hiroyuki Ito：“大脑中的同步活动和认知信息处理”《Brain Medical》第 15 卷，第 37-44 期（2003 年）。

銅谷賢治, 伊藤浩之, 藤井宏, 塚田稔: "脳の情報表現-ニューロン・ネットワーク・数理モデル-"朝倉書店. 230 (2002)

Kenji Doya、Hiroyuki Ito、Hiroshi Fujii、Minoru Tsukada：“大脑中的信息表示 - 神经元网络和数学模型”朝仓书店 230 (2002)。

A.Hirata, P.Maldonado, C.Gray, H.Ito: "Unitary Event Analysis of Synchronous Activities in Cat LGN"The Keio Journal of Medicine. 51, Suppl.1. 81 (2002)

A.Hirata、P.Maldonado、C.Gray、H.Ito：“Cat LGN 同步活动的单一事件分析”庆应义塾医学杂志。