Effects of elastin peptide from fish ductus arteriosus on tissue extensibility

以自发性高血压大鼠（SHR）和无毛大鼠为实验对象，研究鱼动脉导管弹性蛋白肽对血管和皮肤功能的影响。长期给予SHR弹性蛋白肽可减轻血管内皮损伤，保持动脉弹性。Prolyl glysin是弹性蛋白肽的降解产物，可能是弹性蛋白肽的关键序列，连续输注PG可有效预防血管内皮损伤。在体外培养的内皮细胞中，弹性蛋白肽和PG抑制了ICAM-1和Caveoin的表达，而在紫外线照射大鼠模型中，给予弹性蛋白肽的大鼠皮肤弹性高于对照组大鼠。这些结果表明，鱼动脉弹性蛋白肽不仅能有效地保持动脉的弹性，还能有效地保持皮肤的弹性。

Effects of elastin peptide from fish ductus arteriosus on vascular and cutaneous function was investigated using spontaneously hypertensive rats (SHR) or hairless rats. Chronic administration of elastin peptide to SHR resulted in ameriolation of endothelial injury and preservation of arterial elasticity. Prolyl glysin, a degradation product of elastin peptide, may be key sequence of elastin peptide, since continuous infusion of PG to SHR was effective to prevent endothelial injury. In cultured endothelial cells, expression of ICAM-1 and Caveoin was depressed by elastin peptide and PG. In rat model with ultraviolet irradiation, on the other hand, skin elasticity was higher in rats which administered elastin peptide to skin of rats rather than control rats.These results suggest that elastin peptide from fish arteriosus was effective for preservation of elasticity not only in artery but also in skin.