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A PROSPECTIVE COHORT STUDY OF BONE LOSS AND OSTEOPOROTIC FRACTURES IN A RURAL JAPANESE COMMUNITY. THE EFFECT OF NUTRITION, PHYSICAL EXERCISE, ENVIRONMENTAL AND FAMILIAL FACTORS

日本农村社区骨质流失和骨质疏松性骨折的前瞻性队列研究。

基本信息

批准号：
13670383
负责人：
YOSHIMURA Noriko
金额：
$ 2.3万
依托单位：
WAKAYAMA MEDICAL UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

Bone mineral density (BMD) was measured over a ten year period in a cohort study in a mountain village, Wakayama Prefecture, Japan, to provide information on rate of bone loss in the mature and elderly population and to compare the temporal course of BMD between fast bone losers and normal residents.Four-hundred subjects were selected by sex and age from the full list of residents born, in 1910-1949, and BMD of the lumbar spine and proximal femur was measured using dual energy X-ray absorptiometry (DXA) at the baseline, third, severth, and 10th years. Annual rate of change in BMD (% per year) in the lumbar spine in men in their forties, fifties, sixties and seventies was 0.17, 0.55, 0.01 and -0.16, respectively, and in women, -0.87, -0.83, -0.48 and -0.48, respectively. Thus in men, BMD at the lumbar spine increased in all age strata but the oldest, when it decreased, while in women, it decreased in all age strata.MD at the proximal femur decreased in both sexes in all age strata. Our results show that bone loss rates differ depending on die site involved, demonstrating that different strategies are needed for the prevention of bone loss in the spine and hip. Fast bone losers were defined as those subjects demonstrating an excess bone loss that was the greatest tertile of the distribution of bone loss between initial three years, and the rest were classified as normal subjects. Although mean values of BMD at lumbar spine over a ten year period decreased steeply in both fast bone losers and normal subjects, those for fast bone losers was significantly lower than that of normal subjects (P<0.01). However, there was no difference of mean rate of change for BMD over ten years between fast bone losers and normal subjects.

在日本和歌山县的一个山村进行了一项为期10年的队列研究，测定了400名受试者的骨密度（BMD），以提供有关成年和老年人骨丢失率的信息，并比较快速骨丢失者和正常居民BMD的时间进程。采用双能X线骨密度仪（DXA）测量基线、第3年、第7年、第10年腰椎和股骨近端骨密度。40岁、50岁、60岁和70岁男性腰椎BMD的年变化率（%/年）分别为0.17、0.55、0.01和-0.16，女性分别为-0.87、-0.83、-0.48和-0.48。因此，在男性中，腰椎的BMD在所有年龄层中增加，但最老的，当它下降时，而在女性中，它在所有年龄层中下降。我们的研究结果表明，骨丢失率根据所涉及的部位而不同，这表明需要不同的策略来预防脊柱和髋关节的骨丢失。快速骨丢失者被定义为表现出过量骨丢失的受试者，其是最初三年之间骨丢失分布的最大三分位数，其余被归类为正常受试者。10年来，快速骨丢失者和正常人腰椎BMD均急剧下降，但快速骨丢失者明显低于正常人（P<0.01）。但快速骨丢失者与正常人的BMD十年平均变化率无差异。