Development and assessment of a personal evaluation system for risk factors of osteoporosis

骨质疏松症危险因素个人评估系统的开发与评估

• 批准号: 16590512
• 负责人: YOSHIMURA Noriko
• 金额: $ 2.24万
• 依托单位: The University of Tokyo (2005-2006)Wakayama Medical University (2004)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590512/
• 关键词: osteoporosis; primary prevention; life style related diseases; risk assessment; cumulative incidence; cohort study; 個別検診; コホート研究; 骨代謝マーカー; N-mid Osteocalcin; CTX; 基準値; 閉経; 男女差

Bone mineral density (BMD) was measured over a 10-year period in a cohort study in a mountain village in Wakayama Prefecture, Japan, to provide information on cumulative incidence of osteoporosis in the mature and elderly population and to develop an assessment system to predict incidence of osteoporosis using potential risk factors in a baseline questionnaire. Subjects comprised 400 subjects selected randomly by sex and age from a full list of residents born in 1913-1952, and BMD of the lumbar spine and proximal femur was measured using dual energy X-ray absorptiometry (DXA) at baseline and 3, 7 and 10 years. Cumulative incidence of osteoporosis over 10 years in men and women aged in their 40s to 70s was 2.0% and 15.0% at the lumbar spine, respectively, and 10.5% and 18.7% at the femoral neck, respectively. We analyzed the influence of lifestyle factors such as past history, family history, medicines, exercise, dietary habits, alcohol and smoking on cumulative incidence by logistic regression analysis after adjustment for age and gender, but did not find any significant associations. Regression formula for predicting the incidence of osteoporosis at the lumbar spine over 10 years~ was as follows : Y=exp(1.41X1-0.02X2-0.65X3-18.88X4+17.94) (X1: sex, male 0, female 1; X2: age (years), X3: weight (kg), X4: BMD (g/cm2)) R2=43.0%. Conversely, regression formula for predicting the incidence of osteoporosis at the femoral neck over 10 years as follows : Y=exp(-1.94X1+0.02X2-0.04X3-19.22X4+13.63)(X1: sex, male 0, female 1; X2: age (years); X3:weight (kg); X4: BMD (g/cm2)) R2=30.1%. Our study demonstrates that the assessment of lifestyle factors might not be sufficient to predict incidence of osteoporosis.

在日本和歌山县的一个山村进行了一项为期10年的队列研究，测量了骨矿物质密度（BMD），以提供成年和老年人群骨质疏松症累积发病率的信息，并开发了一个评估系统，利用基线问卷中的潜在危险因素预测骨质疏松症的发病率。受试者包括400名受试者，按性别和年龄从1913-1952年出生的居民的完整列表中随机选择，并使用双能X线吸收法（DXA）在基线和3，7和10年测量腰椎和股骨近端的BMD。在40 - 70岁的男性和女性中，10年内腰椎骨质疏松症的累积发病率分别为2.0%和15.0%，股骨颈骨质疏松症的累积发病率分别为10.5%和18.7%。我们分析了生活方式因素的影响，如过去的历史，家族史，药物，运动，饮食习惯，酒精和吸烟的累积发病率进行logistic回归分析调整后的年龄和性别，但没有发现任何显着的关联。预测10年以上腰椎骨质疏松发生率的回归公式为：Y=exp（1.41X1-0.02X2-0.65X3-18.88X4+17.94）（X1：性别，男0，女1; X2：年龄（岁）; X3：体重（kg）; X4：BMD（g/cm 2））R2= 43.0%。相反，预测10年内股骨颈骨质疏松发生率的回归公式如下：Y=exp（-1.94X1+0.02X2-0.04X3-19.22X4+13.63）（X1：性别，男0，女1; X2：年龄（岁）; X3：体重（kg）; X4：BMD（g/cm 2））R2= 30.1%。我们的研究表明，生活方式因素的评估可能不足以预测骨质疏松症的发病率。

项目成果

脆弱性骨折をめぐる諸問題 5.非脊椎骨折 (1)危険因子.

围绕脆性骨折的问题 5. 非椎体骨折 (1) 危险因素。

• 发表时间: 2007
• 期刊: The Bone 21
• 作者: Toshiyuki Ojima;et al.;吉村典子
• 通讯作者: 吉村典子

骨を守る生活習慣を学ぶ.

了解保护骨骼的生活习惯。

• 发表时间: 2005
• 期刊: ホルモンと臨床 53
• 作者: 三浦宏子;荒井由美子;山崎きよ子;吉村典子
• 通讯作者: 吉村典子

Height loss, bone loss and QOL : The Miyama Study.

身高损失、骨质流失和生活质量：Miyama 研究。

• 发表时间: 2005
• 期刊: Osteoporos Jpn 13
• 作者: Nishida N;et al.;三浦 宏子;Yoshimura N.
• 通讯作者: Yoshimura N.

Clinical and social impact of osteoporosis and osteoporotic fractures.

骨质疏松症和骨质疏松性骨折的临床和社会影响。

• 发表时间: 2005
• 期刊: J Japanese Society of Internal Medicine 94
• 作者: Hiratuka;M;Tsukamoto N;Konnno N;Nata M;HAshiyada M;Funayama M;Mizugaki M;Yoshimura N.
• 通讯作者: Yoshimura N.

骨折とEBM I.大腿骨頚部骨折.

骨折和 EBM I. 股骨颈骨折。

• 发表时间: 2004
• 期刊: 骨粗鬆症治療 3
• 作者: Takayanagi K;Asamura H;Tsukada K;Ota M;Fukushima H;吉村典子
• 通讯作者: 吉村典子