Comparison between Barren's intestinal metaplasia and gastric intestinal metaplasia

Barren肠化生与胃肠化生的比较

• 批准号: 13670533
• 负责人: ENDO Takao
• 金额: $ 1.98万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670533/
• 关键词: Barrett's adenocarcinoma; mucin; pit pattern; magnifying endoscopy; narrow band imaging; angiogenesis; Barrett食道; ムチン分子; 腸上皮化生; 拡大内視鏡診

Barrett's esophagus (BE) is an acquired disorder associated with a high incidence of adenocarcinoma. The object of this study was to define the difference among various types of Barrett's mucosa and gastric intestinal metaplastic mucosa. The fine mucosal pattern (pit pattern) of Barrett's mucosa was recorded and compared with methylene blue staining. Histological, mucin immunohistologic, and cell proliferation analyses of biopsy specimens were performed in relation to the pit patterns obtained by magnifying endoscopy. Pit patterns were classified into five categories. Tubular or villous pit patterns were not only characteristics of both SCE and methylene blue absorption but also possessed intestinal mucin phenotype whose Ki-labeling index was high, while other pit patterns, dot or straight pattern, did not have SCE and were categorized into gastric phenotype mucosa. Long oval pit pattern had an intermediate phenotype between these two groups.Classification of superficial mucosal appearance obtained by magnifying endoscopy reflects not only histological features but also mucin phenotypes.

巴雷特食道(BE)是一种获得性疾病，与腺癌的高发病率有关。本研究的目的是明确不同类型的Barrett黏膜和胃肠化生黏膜之间的差异。记录Barrett‘s粘膜的细微形态(小凹形态)，并与亚甲蓝染色结果进行比较。活检标本的组织学、粘蛋白免疫组织学和细胞增殖分析与放大内窥镜获得的凹坑类型有关。坑的图案被分为五类。管状或绒毛状凹陷型不仅具有姐妹染色单体交换和亚甲基蓝吸收的特征，而且还具有肠粘蛋白表型，Ki标记指数较高，而其他凹陷型点状或直型凹陷型则不具有姐妹染色单体交换，属于胃表型黏膜。长椭圆形凹陷型介于这两组之间。通过放大内窥镜获得的浅表黏膜外观的分类不仅反映了组织学特征，而且还反映了粘蛋白表型。

项目成果

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