New visualization technique of radiation effects on cancers

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It would be very desirable to be able to measure directly the oxygen tension in tissues to assess their state and response to therapy. This would be especially desirable for planning and evaluating the radiation therapy for tumors and vascular insufficiencies.The wide variety of techniques for measuring oxygen tensions in biological systems have been reviewed, but one of these methods has been demonstrated for the clinical use. Several NMR techniques have been studied recently, especially the use of an oxygen-dependent proton hyperfine line in myoglobin and oxygen-dependent relaxation of 19F. However, these approaches have not been demonstrated to have sufficient sensitivity and applicability for the real clinical use.Electron paramagnetic resonance (EPR) oximetry is a technique which is based on the effect of molecular oxygen on the line width of EPR spectra of some paramagnetic materials.In this project we used glucose char as the paramagnetic materials and examined its following characterizations : accuracy, sensitivity, ease to use, toxicity, and stability in vivo. From our results, the glucose char appears to have the very good properties than other reported paramagnetic materials.The EPR oximetry using the glucose char will be promising method to measure oxygen tensions in vivo.