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Functional molecular imaging studies by rapid EPR imaging method

Functional molecular imaging studies by rapid EPR imaging method
快速 EPR 成像方法的功能分子成像研究
批准号:
22390236
负责人:
FUJII Hirotada
金额:
$11.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Electron paramagnetic resonance (EPR) imaging using nitroxides is a powerful, noninvasive method for visualizing the redox status modulated by oxidative stress in vivo. However, to date, it has not always been possible to obtain three-dimensional (3D) images with a continuous wave (CW)-EPR imager in small rodents while using nitroxides. Due to improvements in imagers that enable rapid data-acquisition, the feasibility of 3D EPR imaging with good quality in mice was tested with nitroxides of different lipophilicities. The improved CW-EPR imager may be a useful noninvasive tool for assessing changes in the redox status of living subjects under oxidative stress.
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会议论文
グルコース Tempo スピンプローブを用いたEPR イメージング
使用葡萄糖 Tempo 自旋探针进行 EPR 成像
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [藤井博匡, 佐藤慎吾, 江本美穂, 平田拓]
通讯作者: 平田拓
DOI: 10.1039/c0cc03581e
发表时间: 2011-01-01
期刊: CHEMICAL COMMUNICATIONS
影响因子: 4.9
作者: [Pawlak, Anna, Ito, Ryohei, Hirata, Hiroshi]
通讯作者: Hirata, Hiroshi
Redox map of mouse brain by three-dimensional EPR imaging with six-membered nitroxyl radicals
通过六元硝酰基自由基三维 EPR 成像绘制小鼠大脑氧化还原图
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Miho Emoto, Hideo Sato-Akaba, Hiroshi Hirata, Hirotada Fujii]
通讯作者: Hirotada Fujii
Oxygen radical absorbance capacity (ORAC) of cyclodextrin-solubilized flavonoids, resveratrol and astaxanthin as measured with the ORAC-EPR method.
用ORAC-EPR方法测量的环糊精,白藜芦醇和astaxanthin的氧自由基吸收能力(ORAC)。
DOI: 10.3164/jcbn.11-21
发表时间: 2012-03
期刊: Journal of clinical biochemistry and nutrition
影响因子: 2.4
作者: [Sueishi Y, Ishikawa M, Yoshioka D, Endoh N, Oowada S, Shimmei M, Fujii H, Kotake Y]
通讯作者: Kotake Y
16
    Development of early diagnostic method using Alzheimer's disease model mice
    • 批准号:
      20K07829
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2020
    • 负责人:
      FUJII Hirotada
    • 依托单位:
    Simultaneous imaging of multiple bio-functions by EPR imaging method
    • 批准号:
      25670537
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      FUJII Hirotada
    • 依托单位:
    Multiple molecular imaging by EPR spectroscopy
    • 批准号:
      23659592
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2011
    • 负责人:
      FUJII Hirotada
    • 依托单位:
    Functional imaging studies of small rodents by ESR・MRI combined system
    • 批准号:
      19390322
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.98万
    • 财政年份:
      2007
    • 负责人:
      FUJII Hirotada
    • 依托单位:
    海外基金