Assessments of prefrontal function using event-related fMRI

使用事件相关功能磁共振成像评估前额叶功能

• 批准号: 13671033
• 负责人: KIRINO Eiji
• 金额: $ 1.86万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671033/
• 关键词: functional MRI; Event-related potential; schizophrenia; prefrontal cortex; event-related design; face recognition; working memory; LORETA; 精神分裂病; 双極子推定; block design; ダイポール

Functional MRI, ERP, LORETA and can complement the time and spatial resolution of each other. The combination of functional MRI and LORETA is a strong method to evaluate information processing in schizophrenia. We focused on the two main systems; visual processing system and working memory system. Visual sensory inputs are processed in occipitemporal regions through feedforwad and feedback interactions between top-down and bottom-up process. And then mapping between stimulus and responses can be governed in the working memory system in prefrontal cortex. Working memory system has subsystems, called central executive system and slave systems. Experimental tasks and summaries results of are as follows:Working memory system in prefrontal cortex (PFC)Visual oddball paradigmUnderactive in PFC and ACC for infrequently and irregularly presented visual target stimuli/Overactive for task irrelevant novel stimuli in PFC1Deteriorated stimulus-response mapping during goal-directed response for tar … More gets and distractibility to task irrelevant novel stimuliAuditory oddball paradigmFront-temporal dysfunction in passive auditory novelty discriminationResponse competition Deteriorated central executive systemVisual Processing System in Occipitemporal RegionsFace, eyes, eye-movement recognitionUnderactive in face processing in occipitemporal cortex, extrastriatel Overactive for eyes and moving-eyes in the amygdale, insula, and extrastriate cortex 1hypersensitivity in processing of feature details before processing the gestalt of the face or facial expression as a whole, which might be implicated in their deficits in interpersonal skills or forming of a variety of their clinical manifestations such as fear of eye-to-eye confrontation or delusion of reference.Illusory contour perceptionUnderactive in IC processing in extrastriateOveractive for IC in ACC and insulaDeficient in perceptual integration during processing in the extrastriate cortex, which might consequently increase the loads needed in the higher processing in the prefrontal cortexGlobal-Local perceptionUnderactive in Global processing in right occipitemporal cortexOveractive in Local processing in left occipitemporal cortex and PFCLeft hemisphere overactive-right hemisphere underactive in schizophrenic patientsIn the first three experiments, we confirmed working memory deficits in schizophrenia. It is likely that both of subsystems are impaired. In the last three experiments, we confirmed that visual processing systems are impaired as well as working memory system. Deficient processing in the occipitemporal cortex might consequently increase the loads needed in the higher processing in the prefrontal cortex. Impairments of slave system and central executive system might be related with visual processing system. Failure in perceptual integration and bottom-up processing might be implicated in overactivation in insula and amygdala and distractibility in prefrontal cortex. Less

功能MRI、ERP、LORETA又可以在时间和空间分辨率上相互补充。功能性 MRI 和 LORETA 的结合是评估精神分裂症信息处理的有力方法。我们专注于两个主要系统；视觉处理系统和工作记忆系统。视觉感觉输入通过自上而下和自下而上过程之间的前馈和反馈相互作用在枕颞区进行处理。然后，刺激和反应之间的映射可以在前额叶皮层的工作记忆系统中进行控制。工作记忆系统有子系统，称为中央执行系统和从属系统。实验任务和总结结果如下：前额皮质工作记忆系统（PFC）视觉奇怪范式对于不频繁和不规则呈现的视觉目标刺激，PFC和ACC不活跃/PFC1对于与任务无关的小说刺激过度活跃，在目标导向反应过程中刺激-反应映射恶化，对与任务无关的小说的注意力分散 刺激 听觉奇怪范式 被动听觉新奇辨别中的前颞功能障碍 反应竞争 中枢执行系统恶化 枕颞区视觉处理系统 面部、眼睛、眼球运动识别 枕颞皮质、纹状体外的面部处理不活跃 杏仁核、岛叶和纹状体外的眼睛和移动眼睛过度活跃 皮层 1 在处理面部或面部表情整体上的格式塔之前，在处理特征细节时过敏，这可能与他们在人际交往能力方面的缺陷或形成各种临床表现有关，例如害怕面对面的对抗或参照错觉。 纹状体外皮层处理过程中的知觉整合，这可能会增加前额叶皮层高级处理所需的负载全局-局部感知右枕颞皮层全局处理不活跃左枕颞皮层和前额皮质局部处理过度活跃精神分裂症患者左半球过度活跃右半球不活跃 通过三个实验，我们证实了精神分裂症患者的工作记忆缺陷。两个子系统都可能受损。在过去的三个实验中，我们证实视觉处理系统以及工作记忆系统都受到损害。枕颞叶皮层的处理不足可能会增加前额叶皮层高级处理所需的负载。从属系统和中央执行系统的损伤可能与视觉处理系统有关。知觉整合和自下而上处理的失败可能与岛叶和杏仁核的过度激活以及前额皮质的注意力分散有关。较少的

项目成果

桐野衛二: "近い将来に臨床応用が期待される脳イメージング-機能的MRI-"精神科治療学. 16(10). 1049-1053 (2001)

Eiji Kirino：“脑成像有望在不久的将来获得临床应用 - 功能性 MRI”《精神病治疗学》16(10) 1049-1053 (2001)。

桐野衛二, 福田麻由子, 宇田川正子, 池田千佐子, 稲見理絵, 鈴木聡彦, 井上令一, 槇田淳一: "functional MRIを用いた統合失調症の認知機能評価"脳と精神の医学. 14(4). 107-116 (2003)

Eiji Kirino、Mayuko Fukuda、Masako Udakawa、Chisako Ikeda、Rie Inami、Satohiko Suzuki、Reiichi Inoue、Junichi Makita：“使用功能性 MRI 进行精神分裂症的认知功能评估”《脑与精神病学医学》14(4) .107-116 (2003)。

Kirino E: "Correlation between P300 and EEG Rhythm in Schizophrenia"Clinical Electroencephalography. (in press). (2004)

Kirino E：“精神分裂症中 P300 与 EEG 节律的相关性”临床脑电图。

"How does functional MRI contribute to psychiatry? -a review-."Japanese Journal of Psychiatric Treatment. 16(10). 1049-1053 (2001)

“功能性 MRI 对精神病学有何贡献？-评论-。”《日本精神病治疗杂志》。

Ikeda C, Fukuta M, Kirino E, et al.: "functional MRI Study of perception of illusory contour in schizophrenia"Psychiatry and Clinical Neuroscience. 57. S18 (2003)

Ikeda C、Fukuta M、Kirino E 等人：“精神分裂症中虚幻轮廓知觉的功能 MRI 研究”精神病学和临床神经科学。