COGNITIVE FUNCTION OF HEREDITARY HIGH RISK GROUP OF SCHIZOPHRENIA USING EVENT-RELATED POTENTIAL (ERP) AND FUNCTIONAL NEAR INFRARED SPECTROSCOPY (f-NIRS).

使用事件相关电位 (ERP) 和功能性近红外光谱 (f-NIRS) 来研究遗传性高危精神分裂症患者的认知功能。

• 批准号: 12670949
• 负责人: OGURA Chikara
• 金额: $ 0.83万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670949/
• 关键词: Schizophrenia; ERPs; f-NIRS; Hereditary risk; LORETA; 遺伝

This research project examined cognitive function of hereditary high risk group of schizophrenia using event-related potential (ERP) and functional near infrared spectroscopy (f-NIRS). In the event-related potential (ERPs) study. ERPs were examined in 10 schizophrenic subjects (8 male, 2 female, 30.0 +/- 6.1 y.o.), 10 sex matched their siblings (28.8 +/- 2.4 y.o.) and sex-age matched 10 healthy controls (29.0 +/- 3.2 y.o.). ERPs were recorded during an auditory oddball task. Schizotypal Personality Questionnaire (SPQ) was evaluated and correlation of SPQ. Score and ERP results was investigated in sibling group. (Result) 1. Reduced P300 amplitude was found in sibling group as well as schizophrenic group compared to controls. P300 latency did not differ from controls. 2. Positive correlation of P300 amplitude between schizophrenics and their siblings at Pz electrode was found (r = 0.70, p<0.05). 3. Negative correlation between P300 amplitude at Fz electrode and SPO_score was found in sibling group (r = -0.64, p<0.05). 3. LORETA (Low Resolution Electro -magnetic Tomography) analysis of P300 showed reduced cortical current density distribution in the right frontal and bilateral temoral region in both schizoprenics and their siblings compared to controls. In the comparison of schizophrenics and siblings, although both group showed similar cortical current distribution, reduction of current density was notified in the left frontal pole region in schizophrenia compared to siblings. In addition f-NIRS (functional Near Infrared Spectroscopy) examination was undertaken in sibling of schizophrenia showing potential usefulness of f-NIRS to investigate biological substrate of schizophrenia.

本研究采用事件相关电位（ERP）和功能近红外光谱（f-NIRS）技术对精神分裂症遗传性高危人群的认知功能进行了检测。事件相关电位（ERP）研究。对10名精神分裂症患者（8名男性，2名女性，年龄30.0 ± 6.1岁）进行了ERP检查，10名性别匹配的兄弟姐妹（28.8 +/- 2.4岁）10名健康对照组（29.0 ± 3.2岁）。ERPs记录在一个听觉oddball任务。评定分裂型人格问卷（SPQ），并进行相关分析.对同胞组进行量表评分和ERP结果分析。（结果）1.与对照组相比，同胞组和精神分裂症组的P300振幅降低。P300潜伏期与对照组无差异。2.精神分裂症患者与其同胞Pz电极P300波幅呈正相关（r = 0.70，p<0.05）。3.同胞组Fz电极P300波幅与SPO评分呈负相关（r =-0.64，p<0.05）。3. P300的LORETA（低分辨率电磁断层扫描）分析显示，与对照组相比，肾上腺素缺乏症患者及其同胞的右额叶和双侧颞区的皮质电流密度分布降低。在精神分裂症患者和兄弟姐妹的比较，虽然两组表现出相似的皮层电流分布，电流密度的减少被通知在左额极区的精神分裂症相比，兄弟姐妹。此外，对精神分裂症同胞进行了f-NIRS（功能性近红外光谱）检查，显示f-NIRS在研究精神分裂症生物学基础方面的潜在用途。

项目成果

Akira Toyozato, Yasuhide Hukuji, Hiroto Hokama, Ken-Ichi Hiramatsu, Chikara Ogura: "ERPs study of a case of schizophrenia following a five-year prodromal period"Rinshow-shinkei seirigaku. 29(2). 146 (2001)

Akira Toyozato、Yasuhide Hukuji、Hiroto Hokama、Ken-Ichi Hiramatsu、Chikara Ogura：“五年前驱期后精神分裂症病例的 ERPs 研究”Rinshow-shinkei seirigaku。

田中晋, 外間宏人, 王継軍, 安里尚彦, 平松謙一: "分裂病者の事象関連電位(ERPs)P300発生源の治療による変化-Current Density Analysisを用いて-"臨床神経生理学. 29巻2号. 144-145 (2001)

Susumu Tanaka、Hiroto Sotama、Jijun Wang、Naohiko Asato、Kenichi Hiramatsu：“精神分裂症患者事件相关电位 (ERP) 的 P300 源的治疗引起的变化 - 使用电流密度分析 -”《临床神经生理学》第 29 卷，第 1 期。 2.144-145 (2001)

Y.Fukuji, T.Bise, H.Hokama K.Hiramatu, C.Ogura: "Changes of cerebral blood volume in frontal region during mirror drawing task measured by two channel NIRS in Schizophrenics."International Congress Seiries. (出版予定).

Y.Fukuji、T.Bise、H.Hokama K.Hiramatu、C.Ogura：“精神分裂症患者在镜子绘制任务中通过两个通道 NIRS 测量的额叶区域脑血容量的变化。”国际大会系列（即将出版）。

Y.Fukuji, T.Bise, H.Hokama, K.Hiramatu, C.Ogura: "Changes of cerebral blood volume in frontal region during mirror drawing task measured by two channel NIRS in Sehizophrenics"International Congress Seiries(出版予定).

Y.Fukuji、T.Bise、H.Hokama、K.Hiramatu、C.Ogura：“精神分裂症患者镜像绘制任务中通过两通道 NIRS 测量的额叶区域脑血容量的变化”国际大会系列（待出版）。

Yasuhide Fukuji, Tetuhiro Bise, Hiroto Hokama, Ken-Ichi Hiramatsu, C. Ogura: "Changes of cerebral blood volume in frontal resion during mirror drawing task measured by two channel NIRS in Schizophrenics."International Congress Seiries. (in press).

Yasuhide Fukuji、Tetuhiro Bise、Hiroto Hokama、Ken-Ichi Hiramatsu、C. Ogura：“精神分裂症患者在镜子绘制任务期间通过两个通道 NIRS 测量的额叶脑血容量的变化。”国际大会系列。