Simultaneous fMRI-EEG-DTI Recording of MMN in Schizophrenia.

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We simultaneously recorded Mismatch Negativity (MMN) during event-related functional MRI (fMRI) followed by diffusion tensor imaging (DTI) in healthy volunteers and schizophrenic patients. The correlation analysis on SPM revealed significant correlation between FA of the right uncinate fasciculus and BOLD activity in the left Insula. BOLD activity of the right anterior cingulate, the right corpus callosum and right insula significantly correlated with PANSS scores.The dysfunction of Insula, the uncinate fasciculus and the corpus callosum, as well as the temporal lobe and the anterior cingulate gyrus, may specifically contribute to MMN aberration of schizophrenic patients and clinical manifestations reflecting their impaired MMN generation.