Formulation and Characterization of Monodispersed Microcapsules and Nanocapsules

本论文对微胶囊和纳米胶囊的制备和表征进行了研究，主要内容如下：1.采用微通道乳化和溶剂挥发相结合的方法，从单分散的水包油乳液中成功制备了相对单分散的脂质微/纳米粒; 2.对微通道板进行了放大，微通道乳化能力由原来的5 ml/h提高了一个数量级。采用微通道乳化法制备单分散明胶乳液，并以阿拉伯胶为囊材，采用凝聚层法制备阿拉伯胶微囊4.将计算流体力学（CFD）应用于直通式微通道液滴形成的分析。圆形（10 μm）和椭圆形的CFD模型设计了10和40 μm的直通式微通道，模拟结果与实验结果吻合较好。5.研制了新型非对称直通式微通道装置;两层狭缝和微孔结构，并且表现出比传统的对称直通微通道更高的液滴生产率。采用高压均质器对乳化液进行乳化，并对功能性成分的包埋方法进行了新的开发。

Research on Formulation and characterization of microcapsules and nanocapsules has been carried out, and summarized as follows.1.Lipid micro/nanoparticles with relatively monodisperse were successfully obtained from monodispersed oil-in-water emulsion by microchannel emulsification as well as solvent evaporation method.2.Scale up of microchannel plate was done, and microchannel emulsification capacity was increased one magnitute from former 5ml/h productivity.3.Monodispersed gelatin-acacia microcapsules were prepared by formation of monodispersed gelatin emulsion with the use of microchannel emulsification as well as coacervate encapsulation with the use of acacia solution.4.CFD (Computatinal Fluid Dynamics) was applied to the analysis of droplet formation from straight-through microchannel. CFD model of circular (10 μm) and oblong (10 and 40 μm) shaped though holed microchannel was constructed and the simulation results agreed well with the experimental results.5.New device of asymmetric straight-through microchannel has been developed ; two layers of slit and micro-hole structure, and exhibited higher droplet productivity than conventional symmetric straight-through microchannel.6.Formulation of nanoparticles was carried out by protein-based emulsion with the use of high-pressure homogenizer, and the method of encapsulation of functional component was newly developed.