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Formulation and Characterization of Monodispersed Microcapsules and Nanocapsules

单分散微胶囊和纳米胶囊的配制和表征

基本信息

批准号：
14206016
负责人：
NAKAJIMA Mitsutoshi
金额：
$ 25.04万
依托单位：
National Food Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Research on Formulation and characterization of microcapsules and nanocapsules has been carried out, and summarized as follows.1.Lipid micro/nanoparticles with relatively monodisperse were successfully obtained from monodispersed oil-in-water emulsion by microchannel emulsification as well as solvent evaporation method.2.Scale up of microchannel plate was done, and microchannel emulsification capacity was increased one magnitute from former 5ml/h productivity.3.Monodispersed gelatin-acacia microcapsules were prepared by formation of monodispersed gelatin emulsion with the use of microchannel emulsification as well as coacervate encapsulation with the use of acacia solution.4.CFD (Computatinal Fluid Dynamics) was applied to the analysis of droplet formation from straight-through microchannel. CFD model of circular (10 μm) and oblong (10 and 40 μm) shaped though holed microchannel was constructed and the simulation results agreed well with the experimental results.5.New device of asymmetric straight-through microchannel has been developed ; two layers of slit and micro-hole structure, and exhibited higher droplet productivity than conventional symmetric straight-through microchannel.6.Formulation of nanoparticles was carried out by protein-based emulsion with the use of high-pressure homogenizer, and the method of encapsulation of functional component was newly developed.

对微胶囊和纳米胶囊的制备及表征进行了研究，主要总结如下：1.采用微通道乳化法和溶剂蒸发法，从单分散的水包油乳液中成功获得了相对单分散的脂质微纳米粒子。2.对微通道板进行了放大，微通道乳化能力提高了一倍。 3.通过微通道乳化形成单分散明胶乳液以及利用阿拉伯胶溶液凝聚包封，制备单分散明胶-阿拉伯胶微胶囊。4.应用CFD（计算流体动力学）分析直通式微通道液滴形成。建立了圆形(10μm)和椭圆形(10和40μm)带孔微通道的CFD模型,模拟结果与实验结果吻合较好。 5.开发了非对称直通微通道新型装置;两层狭缝和微孔结构，比传统的对称直通式微通道表现出更高的液滴生产率。6.利用高压均质器通过蛋白基乳液进行纳米颗粒的配制，并新开发了功能成分的包封方法。