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The elucidation of regulatory mechanism of food intake in higher animals by the comparison of feeding behavior of broiler- and layer-type chickens.

通过肉鸡和蛋鸡采食行为的比较阐明高等动物食物摄入的调节机制。

基本信息

批准号：
14206033
负责人：
HASEGAWA Shin
金额：
$ 33.28万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Modern broiler-type chickens have been intensively selected for rapid body weight gain and high meat yield, whereas layer-type chickens have been selected for higher egg production. Therfore, genetic selection has introduced wide variations in growth rate between the two strains. The differences in the growth rate could be partly explained by the difference in food intake between the two strains. Research over the past several decades has examined the brain neurochemical systems that regulate food intake in mammalian and avian species, and has identified a number of neurotransmitters that appear to contribute to this behavior. Recently, it has been recognized that regulatory mechanism of food intake in chickens appear similar to that in mammals. Therefore, this study was conducted to elucidation of regulatory mechanism of food intake in higher animals by the comparison of feeding behavior of broiler- and layer-type chickens. First, we investigated the effects of neuropeptide Y, a poten … More t stimulator of food intake, and cocaine- and amphetamine-regulated transcript (CART), a suppressor of food intake, on neonatal broiler- and layer-type chicks and the results indicated that responsiveness to NPY was somewhat different between the two strains. Futehrmore, it was also suggested that CART interacted with NPY in the central nervous system to regulate feeding in chicks. Next, we investigated the differences in hypothalamic catecholamine metabolism and the effects of γ -amino butyric acid (GABA) receptor agonists and antaonists in neonatal broiler- and layer-type chicks and the results indicated that some differences in catecholamine metabolism and in GABAergic systems are present between the two strains. Finally, we investigated the variation of hypothalamic NPY gene expression and peptide content of broiler- and layer-type chickens at neonatal period and the results indicated that the hypothalamic NPY gene expression and peptide content as well as plasma metabolites were changed by feeding conditions. These results suggested that NPY gene expression might be regulated with the blood glucose level and other factors such as leptin might play a role in the regulation of NPY gene expression. As mentioned above, there is the possibility that the differences in the feeding behavior between the two strains is partly due to the differences of responsiveness to NPY, hypoyhalamic cathecholamine metabolism and GABAergic system. Less

现代肉鸡已被集中选择为快速体重增加和高产肉量，而蛋鸡已被选择为更高的产蛋量。因此，遗传选择在两个菌株之间引入了生长速率的广泛变化。生长速率的差异可以部分地由两个菌株之间的食物摄入的差异来解释。过去几十年的研究已经检查了哺乳动物和鸟类调节食物摄入的大脑神经化学系统，并确定了一些似乎有助于这种行为的神经递质。近年来，人们认识到鸡的摄食调节机制与哺乳动物相似。因此，本研究拟通过对肉鸡和蛋鸡摄食行为的比较，阐明高等动物摄食的调控机制。首先，我们研究了神经肽Y的作用， ...更多信息试验结果表明，两个毒株对NPY的反应性存在一定的差异。此外，CART还可能与中枢神经系统中的NPY相互作用，调节雏鸡的摄食。其次，我们研究了新生肉鸡和蛋鸡下丘脑儿茶酚胺代谢的差异以及γ -氨基丁酸（GABA）受体激动剂和拮抗剂的作用，结果表明，两种品系之间的儿茶酚胺代谢和GABA能系统存在一定差异。最后，研究了新生期肉鸡和蛋鸡下丘脑NPY基因表达和肽含量的变化，结果表明，饲养条件改变了下丘脑NPY基因表达和肽含量以及血浆代谢产物。这些结果提示，NPY基因表达可能受血糖水平的调节，瘦素等因素可能也参与了NPY基因表达的调节。如上所述，两种品系之间摄食行为的差异可能部分是由于对NPY、下丘脑性胆碱代谢和GABA能系统的反应性差异。少

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Feeding condition and strain difference influence sleeping behavior in newborn chicks.

喂养条件和品系差异影响新生雏鸡的睡眠行为。

DOI：
发表时间：
2003
期刊：
Journal of Poultry Science 第40巻・第1号
影响因子：
0
作者：
Sato;S.
通讯作者：
S.

Comparison of hypothalamic monoamines contents of broiler- and layer-type chickens at prehatch and posthatch.

肉鸡和蛋鸡孵化前和孵化后下丘脑单胺含量的比较

DOI：
发表时间：
2003
期刊：
Journal of Poultry Science 第40巻・第4号
影响因子：
0
作者：
Yamasaki;I.
通讯作者：
I.

Differences in in catecholamine metabolism and behavior in neonatal broiler and layer chicks.

新生肉鸡和蛋鸡儿茶酚胺代谢和行为的差异。

DOI：
发表时间：
2004
期刊：
British Poultry Science 45
影响因子：
0
作者：
Saito S;Takagi T;Koutoku T;Saito E-S;Hirakawa H;Tomonaga S;Tachibana T;Denbow DM;Furuse M
通讯作者：
Furuse M

Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleep-like behavior induced by L-pipecolic acid in the neonatal chick.

脑室内给予 GABA-A 和 GABA-B 受体拮抗剂可减弱新生雏鸡由 L-哌可酸诱导的进食和睡眠样行为。