Fundamental research on identification and its control of the priming factor in liver cancer proliferation

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1)In 42 human HCC samples, IL-8 expression and its biological and clinical significance was studied. Using RT-PCR to IL-8 mRNA, 32 HCC samples were positive of IL-8. IL-8 expression of tumor tissue was not correlated with its angiogenesis studied by CD34 immunostaining. Hence, the incidence of vessel involvement was much higher in IL-8 positive group than in IL-8 negative group (n=10). Thus, TNM staging of HCC in positive group was higher than that in negative group. Overall, it is concluded that IL-8 expression in HCC may affect tumor cell behavior more than angiogenesis.2)In rat-hepatocrcinogenesis induced by Diethylnitrosamin (DEN), liver weight and cancer volume were increased at 17-week DEN administration. Moreover, tissue MDA level was increased, and tissue NF-κB activation and the increase of iNOS level were shown. TNP470 (50mg/kg) and Roxithromicin (RXM 100mg/kg) inhibited the NF-κB activation and the following iNOS and MDA level.3)By using nude mouse- dorsal bag model, it is shown that RXM inhibited tumor angiogenesis of HepG2.